About Us

Simon Knight

Simon Knight

Co-Director

[email protected]

Simon undertook his undergraduate studies at Corpus Christi College, Cambridge, gaining a BA in medical science in 2000 before studying clinical medicine at Addenbrooke's Hospital, Cambridge . He qualified as a doctor in 2002, and having completed his pre-registration year moved to Nottingham for his Basic Surgical Training. He completed his MRCS in December 2005 and moved to Oxford in May 2006 to take up a position as a clinical research fellow in transplant surgery, during which time he completed his Master of Surgery (MChir) thesis with the University of Cambridge. On returning to higher surgical training he remained on the staff of the CET as a consultant during his time as an NIHR Academic Clinical Lecturer.

Simon has now taken up post as a Senior Clinical Research fellow and Honorary Consultant Transplant Surgeon at the Oxford Transplant Centre. Following Peter Morris' retirement from the CET in July 2016, he has now taken on the role of Co-Director with Liset Pengel.

During his time at the CET, Simon has performed a number of systematic reviews relating to the optimisation of immunosuppressive therapies. These include therapeutic drug monitoring and steroid sparing regimens. A number of these reviews have been published in peer reviewed journals and presented as national and international conferences. His work on steroid sparing regimens won the 2009 clinical Medawar medal from the British Transplant Society. The work performed during his time as a research fellow was accepted as a thesis for the degree of Master of Surgery at Cambridge University, and awarded the MChir distinction prize and Sir Walter-Langdon Brown prize.

Simon is now involved in a number of review projects with the CET, supervising both academic foundation trainees and a DPhil candidate. His university role as a Senior Research Fellow is affording him more time to pursue an interest in clinical trial design, and he is involved in the COPE project (European multicentre trials in organ preservation) and a number of other current an upcoming clinical trials.

Outside of medicine Simon has an interest in technology and computers, with considerable experience in web design.

Publications

Macklin PS, Morris PJ, Knight SR. A systematic review of the use of rituximab for the treatment of antibody-mediated renal transplant rejection. Transplantation Reviews 2017; 31(2): 87-95. [PMID:28187998]

Sautenet B, Tong A, Manera KE, Chapman JR, Warrens AN, Rosenbloom D, Wong G, Gill J, Budde K, Rostaing L, Marson L, Josephson MA, Reese PP, Pruett TL, Hanson CS, O'Donoghue D, Tam-Tham H, Halimi JM, Shen JI, Kanellis J, Scandling JD, Howard K, Howell M, Cross N, Evangelidis N, Masson P, Oberbauer R, Fung S, Jesudason S, Knight S, Mandayam S, McDonald SP, Chadban S, Rajan T, Craig JC. Developing Consensus-Based Priority Outcome Domains for Trials in Kidney Transplantation: A Multinational Delphi [PMID:28738403]

Ceresa CD, Nasralla D, Knight S, Friend PJ. Cold storage or normothermic perfusion for liver transplantation: probable application and indications. Curr Opin Organ Transplant 2017; 22(3): 300-305. [PMID:28301388]

O'Donoghue KJM, Reed RD, Knight SR, O'Callaghan JM, Ayaz-Shah AA, Hassan S, Weißenbacher A, Morris PJM, Locke J, Pengel LHM. Critical appraisal of international clinical practice guidelines in kidney transplantation using the Appraisal of Guidelines for Research and Education (AGREE) II tool: A systematic review. 2017 (Accepted Abstract at the BTS Congress, Yorkshire, UK, 1-3 March, 2017).

O’Donoghue KJM, Reed RD, Knight SR, O’Callaghan JM, Ayaz-Shah AA, Hassan S, Morris PJ, Pengel LHM. Systematic review of clinical practice guidelines in kidney transplantation. BJS Open 2017; 1(4): 97–105.

Knight SR, Morris PJ, Schneeberger S, Pengel LH. Trial design and end points in clinical transplant research. Transpl Int. 2016;29(8):870-9 [PMID:26749215]

O'Donoghue KJM, Deierhoi RJ, Knight SR, O'Callaghan JM, Morris PJ, Locke J, Pengel LHM. Critical Appraisal of Clinical Practice Guidelines in Kidney Transplantation using the Appraisal of Guidelines for Research and Education (AGREE) II tool: A Systematic Review. 2016. (Poster presentation at the BTS Congress, Glasgow, UK, 24-26 February, 2016).

Knight SR. Intra-patient variability in tacrolimus exposure - a useful tool for clinical practice? Transpl Int. 2016; 29(11):1155-1157 [PMID:27283231]

Jochmans I, Akhtar MZ, Nasralla D, Kocabayoglu P, Boffa C, Kaisar M, Brat A, O'Callaghan J, Pengel LH, Knight S, Ploeg R. Past, present and future of dynamic kidney and liver preservation and resuscitation. Am J Transplant. 2016 [Epub ahdead of print] [PMID:26946212]

Knight SR, Hussain S. Variability in the reporting of renal function endpoints in immunosuppression trials in renal transplantation: time for consensus? Clin Transplant. 2016;30(12):1584-1590. [PMID:27740730]

Hussain S, Knight SR. Quality and consistency of outcome reporting in clinical trials of immunosuppression in renal transplantation. Clinical Transplantation. 2016;30(11):1440-1448. [PMID:27582408]

Knight SR, Metcalfe L, O’Donoghue K, Ball ST, Beale A, et al. (2016) Defining Priorities for Future Research: Results of the UK Kidney Transplant Priority Setting Partnership. PLoS ONE 11(10): e0162136

O'Callaghan JM, Knight SR, Morgan RD, Morris PJ. A National Registry Analysis of Kidney Allografts Preserved With Marshall's Solution in the United Kingdom. Transplantation. 2016 Nov;100(11):2447-2452. [PMID:26760566]

Macklin PS, Morris PJ, Knight SR. A systematic review of the use of rituximab as induction therapy in renal transplantation. Transplant Rev. 2015; 29(2):103-8. [PMID:25555541]

Pengel LHM, Knight SK, Morris PJ. Transplant Library - the definitive resource of high quality evidence in solid organ. RCS Annual Day 2014 and SITU’s Launch, March 26, 2014, University of Oxford, UK.

O'Callaghan JM, Morgan RD, Knight SR and Morris PJ. The Effect of Preservation Solutions for Storage of Liver Allografts on Transplant Outcomes: A Systematic Review and Meta-analysis. Annals of Surgery. 2014 Jul; 260(1):46-55 [PMID:24374537]

Som R, Morris PJ and Knight SR. Graft Vessel Disease Following Heart Transplantation: A Systematic Review of the Role of Statin Therapy. World Journal of Surgery 2014; DOI:10.1007/s00268-014-2543-x [PMID:24700094]

Knight S, Vogel T and Friend P. Pancreas Transplantation. Surgery 2014; 32(7): 383–388

MacKlin P, Morris PJ and Knight SR. A Systematic Review of the Use of Rituximab for Desensitization in Renal Transplantation. Transplantation 2014; 98(8):794-805 [PMID:25321163]

Knight SR. Social media and online attention as an early measure of the impact of research in solid organ transplantation. Transplantation. 2014 Sep 15;98(5):490-6 [PMID:25061904]

Evans JDW, Morris PJ and Knight SR. Antifungal Prophylaxis In Liver Transplantation: A Systematic Review And Network Meta-Analysis. American Journal of Transplantation 2014;14(12):2765-76 [PMID:25395336]

O'Callaghan J, Knight S, Morgan R, Morris P. A national registry analysis of kidney allograft preservation with Marshall's Solution in the United Kingdom (Poster presentation at the World Transplant Congress, San Francisco, 2014)

O'Callaghan J, Knight S, Morgan R, Morris P. A national registry analysis of kidney allograft presentation with Marshall's Solution in the United Kingdom. (Oral at the British Transplantation Society, Glasgow 2014)

O'Callaghan JM, Morgan RD, Knight SR, Morris PJ. Systematic review and meta-analysis of hypothermic machine perfusion versus static cold storage for kidney allografts on transplant outcomes. British Journal of Surgery. 2013 Jul; 100(8):991-1001. [PMID:23754643]

O'Callaghan J, Morgan R, Knight S, Morris P. Systematic reviews of alemtuzumab in renal transplantation. Transplant Immunology. March 2013; 28 (2): 71. [PMID:23352935]

Pengel LHM, Knight S, Emin A, O’Callaghan J, Van der Meulen J, Papalois V, Morris PJ. How to teach evidence-based skills in 1.5 days: the Evidence in Transplantation (EVIT) Course. 16th Congress of the European Society for Organ Transplantation, September 8-11, 2013, Vienna, Austria

Macklin P,Knight S, Morris P. A systematic review of rituximab as desensitisation therapy in renal transplantation. (Poster presentation at the Joint British Transplantation Society and Renal Association Congress, Bournemouth, March 2013)

O'Callaghan J, Morgan R, Knight S, Morris P.Preservation solutions for static cold storage of liver allografts: A systematic review and meta-analysis. 16th Annual Congress of the British Transplantation Society, Bournemouth, 2013.

Knight SR, Pengel LHM, Morris PJ. Chapter 42: Evidence in Transplantation in Kidney Transplantation: Principles and Practice. 7th edition. Eds. P. J. Morris and Stuart J Knechtle, Elsevier, Philadelphia. p729- 736

Knight SR. Chapter 16: Steroids in Kidney Transplantation: Principles and Practice. 7th edition. Eds. P. J. Morris and Stuart J Knechtle, Elsevier, Philadelphia. p221-230

O'Callaghan J, Morgan R, Knight S, Morris P. Liver allograft preservation fluids: A systematic review and meta-analysis. Transplant International. 2013; 26(Supp s2):332

Pengel LHM, Knight S, Emin A, O'Callaghan J, Van der Meulen J, Papalois V, Morris P. How to teach evidence-based practice skills in 1.5 days: the Evidence in Transplantation (EVIT) course. Transplant International. 2013; 26(Supp s2);192

O'Callaghan J, Morgan R, Knight S, Morris P. Liver allograft preservation fluids: A Systematic review and Meta-Analysis. (Poster presentation at the European Society for Organ Transplantation, Vienna 2013)

Pengel L, Knight S, Emin A, O'Callaghan J, Van der Meulen J, Papalois V, Morris P. How to teach evidence-based practice skills in 1.5 days: The Evidence in Transplantation (EVIT) Course. (Poster presentation at the European Society for Organ Transplantation, Vienna 2013)

O'Callaghan JM, Knight SR, Morgan RD, Morris PJ. Preservation solutions for static cold storage of kidney allografts: a systematic review and meta-analysis. American Journal of Transplantation 2012; 12(4): 896-906. [PMID:22221739]

Morgan RD, O'Callaghan JM, Knight SR, Morris PJ. Alemtuzumab induction therapy in kidney transplantation: a systematic review and meta-analysis. Transplantation 2012; 93(12): 1179-1188 [PMID:22660659]

O’Callaghan J, Morgan R, Knight S, Morris P. Hypothermic machine preservation in comparison with static cold storage for kidney allografts. The Transplantation Society Congress, Berlin 2012

Morgan RD*, O’Callaghan JM, Knight SR, Morris PJ. Alemtuzumab induction therapy in kidney transplantation: a systematic review and meta-analysis. 24th International Congress of The Transplantation Society, Berlin, Germany. * presenting author

Morgan R, O'Callaghan J, Knight S, Morris P. Alemtuzumab induction therapy in kidney transplantation: A Systematic Review and Meta-Analysis. Transplantation. 2012; 94(10S):972

O'Callaghan J, Morgan R, Knight S, Morris P. Hypothermic machine preservation in comparison with static cold storage for kidney allografts: A Systematic review and Meta-Analysis. Transplantation. 2012; 94(10S):277

Knight SR, Morris PJ. Steroid avoidance or withdrawal in renal transplantation. Transplantation 2011; 91(5):e25; author reply e26-7 [PMID:21336081]

Knight SR, Morris PJ. Steroid sparing protocols following nonrenal transplants; the evidence is not there. A systematic review and meta analysis. Transplant International 2011; 24(12): 1198-1207 [PMID:21923805]

Knight SR, Morris PJ. Interaction between maintenance steroid dose and the risk/benefit of steroid avoidance and withdrawal regimens following renal transplantaion. Transplantation 2011; 92(11): e63-4

O’Callaghan J, Knight S, Morgan R, Morris P. Preservation solutions for static cold storage of kidney allografts. Oral- European Society of Organ Transplantation, Glasgow 2011

O'Callaghan J, Morgan R, Knight S, Morris P. Preservation solutions for static cold storage of kidney allografts: A Systematic Review and Meta-Analysis. Transplant International. 2011; 24(s2):204

Knight SR and Morris PJ. Steroid avoidance or withdrawal following renal transplantation increases the risk of acute rejection but decreases cardiovascular risk. A meta-analysis. Transplantation 2010. Jan 15; 89 (1): 1-14 [PMID:20061913]

Currie AC, Knight SR and Morris PJ. Tuberculosis in Renal Transplant Recipients: The Evidence for Prophylaxis. Transplantation 2010; 90(7): 695-704 [PMID:20647975]

Knight SR. Optimisation of Immunosuppressive drug therapy in Transplant Recipients. MCh. Thesis, University of Cambridge. 2009.

Knight SR, Russell NK, Barcena L, Morris PJ. Mycophenolate mofetil decreases acute rejection and may improve graft survival. A systematic review. Transplantation 2009;87(6):785-94 [PMID:19300178]

Knight SR, Morris PJ. Azathioprine and Steroids in Kidney Transplantation: Principles and Practice 6th Edition (eds. Morris PJ & Knechtle S), 2008: p220

Russell NK, Knight SR and Morris PJ. Cyclosporine in Kidney Transplantation: Principles and Practice 6th Edition (eds. Morris PJ & Knechtle S), 2008: p234

Knight SR and Morris PJ. Does the evidence support the use of Mycophenolate Mofetil therapeutic drug monitoring in clinical practice? A systematic review. Transplantation 2008; 85(12): 1675-1685. [PMID:18580456]

Knight SR and Morris PJ. In response to: Benefit of neoral C2 monitoring in de novo cardiac transplant recipients receiving basiliximab induction. Transplantation 2008 Sep 27;86(6):885 [PMID:18813115]

Knight, SR, Friend PJ, Morris PJ (2007) Role of transplantation in the management of hepatic malignancy. Brit J. Surg. 2007; 94(11) : 1319-30 [PMID:17939138]

Knight SR and Morris PJ. The clinical benefits of cyclosporine C2-level monitoring: a systematic review. Transplantation 2007; 83(12):1525-35 [PMID:17589331]