Become part of our team: we are looking for an information specialist

Posted by Liset Pengel on January 29, 2015

We are looking for a dedicated information specialist to work with our team based in London.

The successful candidate will be responsible for keeping our Transplant Library database up to date with the latest high-quality evidence.

More information about the job and the person specification can be found here.

Presumed consent in organ transplantation is unnecessary and ethically unsound

Posted by Peter Morris on January 6, 2015

Professor John Fabre, Past President of the British Transplant Society, has written an extremely well argued case against presumed consent in organ donation stating that it is both clinically unnecessary and that it would compromise the ethics of clinical practice. The author argues in this article that rather than legislating for consented donors we should be addressing the misgivings and misunderstandings of families in order to improve their consent rate.  If the consent rate for deceased donation could be raised in the UK from around 55% to the Spanish rate of 85% this would have an enormous impact on the number of organs available.

This article is recommended reading for all those associated with organ transplantation.

Sirolimus associated with less malignancy but an increased mortality after kidney transplantation

Posted by Peter Morris on January 6, 2015

A group from Ottawa, led by Greg Knoll, have published an important systematic review of risk of cancer in patients who had sirolimus included with their immunosuppression de novo as well as those who were converted at some stage after transplantation to sirolimus. The study also included a meta-analysis of individual patient data. This was available from 5,676 patients from 21 randomised trials. Sirolimus was associated with a 40% reduction in the risk of malignancy and particularly in the reduction of the risk of a non-melanoma skin cancer, compared with patients who did not receive sirolimus. The most marked effect was seen in patients who were converted to sirolimus at some time following the transplant procedure.

However sirolimus was associated with a 43% increased risk of death compared with controls. The causes of death in sirolimus patients were either infection or cardiovascular. The authors suggest that although there is a reduction in the risk of malignancy, the increased risk of death in patients receiving sirolimus does not justify its use. This may well be true but this is a critically important study and no doubt will trigger others to look specifically at mortality in their patients who are receiving, or have received, an mTOR inhibitor.

Texas Transplantation Society – first society in the US to subscribe to the Transplant Library database

Posted by Liset Pengel on November 20, 2014

We are very pleased to announced that from January 1, all members of the Texas Transplantation Society will have access to the Transplant Library.

Texas Transplantation Society is the first American organization to offer access to its members. The subscription is made possible, in part, through funds donated to the Baylor Health Care System Foundation.

Read the official press release here.

We’re hiring – come and work as a research fellow with the CET!

Posted by Simon Knight on October 27, 2014

The Centre for Evidence in Transplantation are currently advertising a research fellow post for someone to join our team at Oxford University.  The successful candidate will be working on a project to develop Core Outcome Sets for clinical trials in Transplant surgery.  The post involves literature search and systematic review, as well as qualitative research methodology working with consensus panels.

The post is initially funded for one year, but we hope to extend to three years subject to funding and progress.  For more information, read the full job description or contact Simon Knight at [email protected].

Learn more about statistics for evidence appraisal during EVIT 2015

Posted by Liset Pengel on October 23, 2014

The programme for the Evidence in Transplantation (EVIT) course has been finalised and now includes the following statistical session:

” An introduction to statistics for evidence appraisal”
• Reviewing outcome measures, common measures of association and intervention effects
• Interpreting p-values and confidence intervals

The workshop will be given by Dr Susan Charman, lecturer in medical statistics at the London School of Hygiene and Tropical Medicine.

Other topics covered by the EVIT course include:
• Introduction to evidence-based medicine
• Literature searching
• Introduction to statistics for evidence appraisal
• Evidence appraisal
• Systematic review and meta-analysis workshop

To view the detailed programme and to register for the course, please visit the ESOT website

National survey on kidney transplant research now open

Posted by Simon Knight on October 1, 2014

psp_logo_redA new national survey has opened, giving patients, their carers and the healthcare professionals looking after them an opportunity to submit questions about kidney transplantation and living donation that they think should be addressed in future research.

The survey is open to all healthcare professionals caring for people who have had a kidney transplant, are on the transplant waiting list or living donors. The questions you ask will help inform future research and will be highly valuable to researchers and research funders.

Please visit the Kidney Transplant PSP website until the 30th of November to participate. It should take no longer than 10 minutes to complete.

Deadline approaching for ESOT’s Hepatologist and Nephrologist in a Transplant Program (HNTP) Course

Posted by Liset Pengel on September 22, 2014

The deadline for ESOT’s “Hepatologist and Nephrologist in a Transplant Program (HNTP)” course is September 30.

The HNTP course is an advanced ESOT course for physicians with a strong career interest in Transplantation

The educational objectives are:

  • To meet the experts on Transplant Medicine
  • To obtain specific knowledge and skills on medical aspects of Liver Transplantation
  • To obtain specific knowledge and skills on medical aspects of Kidney Transplantation
  • To exchange experience with other fellows aimed to develop their career in Transplant Medicine

Sign up now through the ESOT website.

September 2014 Transplant Trial Watch now online

Posted by Simon Knight on September 2, 2014

After a 1 month break for the World Transplant Congress, the September 2014 edition of the Transplant Trial Watch is now available on the CET website and via our mobile app.

This month, studies include an interesting analysis of the relationship between uric acid levels and CAN from the ABCAN trial, de novo Belatacept in liver transplantation and Alemtuzumab induction in lung transplantation.

World Transplant Congress

Posted by Peter Morris on August 27, 2014

The World Congress in Transplantation, which was a joint meeting between the TTS, the ASTS and the AST took place in San Francisco from the 26th to the 31st of July. It was a huge meeting with some 7,000 people attending which made it quite difficult to meet people.

The opening ceremony was rather special and quite different to the usual displays of the culture of the host city/state in that two outstanding talks were given by the father of a donor and a recipient of a lung transplant.

The first was by Reginald Green, the father of a little child, Nicholas, who had died during a bandit attack while holidaying in Italy with his wife and two children in 1994. He and his wife decided that he should be an organ donor. This caused a sensation at the time in Italy as organ donation was one of the lowest in Europe. Seven Italians benefited from his organs and corneas. The father has since set up a foundation to further the cause of organ donation ( This was a spellbinding account of this family’s sorrow but also demonstrating what he has done in the cause of organ transplantation to overcome the donor shortage, which is nowhere more evident than in Italy where the organ donation rate has quadrupled. There is a new edition of his highly acclaimed book “The Nicholas Effect”.

The second presentation was by a young woman, Charity Sunshine Tilleman-Dick, who is an opera singer. She opened her lecture with an aria from Rigoletto and then went on to explain how she was struck down with a lung condition early in her career and this required a double lung transplant. She returned to opera singing but several years’ later rejection was taking place and she had to have a second double lung transplant! Again this has been successful and she is back singing, and certainly the audience were in a position to vouch for her singing ability.

What a remarkable two stories. The large audience was spellbound as was the writer.

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