The CET-ESOT Collaboration.

The Centre for Evidence in Transplantation and the European Society for Organ Transplantation (ESOT) have initiated a collaboration and have agreed that the CET will become the Knowledge Centre for ESOT. The collaboration focusses on helping with the design and reporting of randomised controlled trials in Europe, and with conducting and publishing high quality systematic reviews.

The collaboration has also led to the Evidence in Transplantation (EVIT) course and the monthly Transplant Trial Watch.


The aim of the collaboration is several fold but one major project is to improve the methodological quality of European transplantation trials by advising investigators in the early stages of trial design and planning. An analysis of all randomized controlled trials (RCTs) in organ transplantation between 2004 and 2006 has shown that only around one third of trials were of good methodological quality. This detracts from the value of the evidence provided by these poor RCTs.

How can we help you?

  • Receive expert advice with the design of randomised controlled trials.
    The CET can help with the design of trials and critical review of trial protocols. Trial protocols submitted to the CET will undergo a comprehensive review of all sections of the protocol to ensure it meets the fundamental methodological standards. Please refer to the SPIRIT statement before submitting your protocol. A SPIRIT checklist is available which should be submitted with your protocol. The CET on final approval of a trial protocol would issue accreditation of the trial and a trial number.

  • ESOT members can receive help with systematically searching and reviewing the literature.
    The CET will advise on how to design a search strategy, the databases to search and how to download and sift the retrieved references. ESOT members can also submit a manuscript describing a systematic review to the CET for critical review. CET will ensure that the manuscript addresses all the items of the PRISMA statement, a requirement of many leading journals.

Who is it for?

This free service is available to ESOT members or any residents of Europe.

Submit a trial protocol for review by the CET

To receive help with any of the services listed above, please contact us.