News

ACADEMIA – a new course from ESOT, Vienna May 2018

By: Simon Knight | Posted on 9th January 2018

The European Society in Organ Transplantation and the Centre for Evidence in Transplantation have teamed up to create a new course for future leaders in transplantation.  Replacing the Evidence in Transplantation (EVIT) course and European Transplant Fellows Workshop (ETFW), this new course aims to teach: Academic skills – research, critical appraisal, evidence based medicine, systematic […]

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Do clinical trials reflect reality?

By: Simon Knight | Posted on 9th January 2018

Renal transplant recipients and donors are becoming increasingly more marginal, with more expanded criteria (ECD) and donation after circulatory death (DCD) donors and increasingly older recipients with multiple comorbidities. Despite this, high-risk donors and recipients are often excluded from clinical trials, leading to uncertainty about the generalizability of findings. In order to highlight the extent of this […]

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Intra-ductal stents in live donor liver transplantation increases the risk of biliary leaks.

By: John O'Callaghan | Posted on 2nd January 2018

In this recent RCT by Kumar et al the use of intra-ductal (trans-anastomotic) stents in live donor liver transplantation increased the risk of biliary leaks (36% versus 12%). The authors found that bile leak was also associated with an increased risk of biliary stricture. The authors speculated that the reason for the increased risk of bile leak […]

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December 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 4th December 2017

The December 2017 edition of the Transplant Trial Watch is now available online. This month’s studies include PDT vs. Imiquimod for the treatment of actinic keratoses in transplant recipients, omitting affective attitude questions to improve intention to become an organ donor, and a meta-analysis of ECMO vs. bypass during lung transplantation.

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November 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 1st November 2017

The November 2017 Transplant Trial Watch is now available. This month’s papers include a non-inferiority study of low-dose sirolimus combined with tacrolimus in renal tranpslant recipients, a meta-anlysis of remote ischaemic conditioning protocols, and propofol to reduce hepatic ischaemia reperfusion injury.

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The PITHIA trial – a novel trial to improve kidney utilisation

By: Simon Knight | Posted on 4th October 2017

Soon to start recruiting in the UK, the Pre-Implantation Trial of Histopathology In renal Transplant Allografts (PITHIA) trial blends national collaboration, a unique digital pathology service, registry-based follow-up and a novel stepped-wedge design to assess the impact of a national donor histopathology service on kidney utilisation. The trial is being run by chief investigator Gavin […]

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October 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 4th October 2017

The October 2017 edition of the Transplant Trial Watch is now available. This month’s studies include long term results from the original phase II Belatacept study, a Cochrane review of monoclonal and polyclonal antibodies for renal transplant recipients, and a systematic review of in-situ perfusion techniques in liver transplantation.

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Do you work on Surgical Trials?

By: Simon Knight | Posted on 14th September 2017

Do you work in surgical trials? If so the PIRRIST team need your help! They are looking for surgical trial staff (in a variety of roles) to take part in an online questionnaire about their experiences of some barriers to successful recruitment, retention and PPI in UK adult surgical /surgery-related trials. They are offering a £10 […]

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September 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 6th September 2017

The September 2017 edition of the Transplant Trial Watch is now online. This month’s studies include paracalcitol in renal transplant recipients, a new formula for estimation of standard liver volume, and protective mechanical lung ventilation in lung transplantation.

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Management of asymptomatic bacteriuria after kidney transplantation – survey

By: Simon Knight | Posted on 6th July 2017

The ERA-EDTA DESCARTES working group have developed a short survey to collect information regarding current practice on the diagnosis and management of asymptomatic bacteriuria after adult kidney transplantation. This survey complements a clinical trial that they are running in this area. They would be very keen to hear from units in the UK so that […]

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