News

Do clinical trials reflect reality?

By: Simon Knight | Posted on 9th January 2018

Renal transplant recipients and donors are becoming increasingly more marginal, with more expanded criteria (ECD) and donation after circulatory death (DCD) donors and increasingly older recipients with multiple comorbidities. Despite this, high-risk donors and recipients are often excluded from clinical trials, leading to uncertainty about the generalizability of findings. In order to highlight the extent of this […]

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December 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 4th December 2017

The December 2017 edition of the Transplant Trial Watch is now available online. This month’s studies include PDT vs. Imiquimod for the treatment of actinic keratoses in transplant recipients, omitting affective attitude questions to improve intention to become an organ donor, and a meta-analysis of ECMO vs. bypass during lung transplantation.

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The PITHIA trial – a novel trial to improve kidney utilisation

By: Simon Knight | Posted on 4th October 2017

Soon to start recruiting in the UK, the Pre-Implantation Trial of Histopathology In renal Transplant Allografts (PITHIA) trial blends national collaboration, a unique digital pathology service, registry-based follow-up and a novel stepped-wedge design to assess the impact of a national donor histopathology service on kidney utilisation. The trial is being run by chief investigator Gavin […]

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October 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 4th October 2017

The October 2017 edition of the Transplant Trial Watch is now available. This month’s studies include long term results from the original phase II Belatacept study, a Cochrane review of monoclonal and polyclonal antibodies for renal transplant recipients, and a systematic review of in-situ perfusion techniques in liver transplantation.

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September 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 6th September 2017

The September 2017 edition of the Transplant Trial Watch is now online. This month’s studies include paracalcitol in renal transplant recipients, a new formula for estimation of standard liver volume, and protective mechanical lung ventilation in lung transplantation.

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June 2017 Transplant Trial Watch now online

By: Simon Knight | Posted on 2nd June 2017

The June 2017 edition of the Transplant Trial Watch is now available. This month’s studies include potential for tacrolimus overdosing in obese transplant recipients, chlorthalidone for the management of hypertension in kidney transplant recipients, terlipressin in live donor liver transplantation and desmopressin use in cardiac transplantation.

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April 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 4th April 2017

The April 2017 Transplant Trial Watch is now available online and via the TTW app for iPhone, iPad and android. This month, studies include a meta-analysis of RAS blockade in renal transplant recipients, early vs. late removal of ureteric stents, and development of a transplant risk index for patients on mechanical circulatory support.

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March 2017 Transplant Trial Watch now online

By: Simon Knight | Posted on 28th February 2017

The March 2017 edition of the Transplant Trial Watch is now available. This month’s papers include telemedicine for live donor follow-up, ACE inhibitors in renal transplant recipients and cancer screening recommendations following solid organ transplantation.

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February 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 1st February 2017

The February 2017 edition of the Transplant Trial watch is now available. This month, studies include novel monoclonal antibodies for prevention of CMV viraemia post-transplant, diagnostic markers for acute kidney rejection and chronic kidney injury, and portocaval shunts in liver transplantation.

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January 2017 Transplant Trial Watch now available

By: Simon Knight | Posted on 6th January 2017

The January 2017 edition of the Transplant Trial Watch is now available. This month, trials include risk of infection with RANKL inhibitors, kidney cooling during anastomosis and donor ischaemia preconditioning in liver transplantation.

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