Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.


May 2015

Kidney transplantation

Daclizumab Versus Rabbit Antithymocyte Globulin in High-Risk Renal Transplants: Five-Year Follow-up of a Randomized Study
Hellemans R, Hazzan M, et al. American Journal of Transplantation. 2015 Jul; 15(7): 1923-32

Low dose pamidronate for treatment of early bone loss following kidney transplantation. A randomized controlled trial
Shahidi S, Ashrafi, F et al Iranian Journal of Kidney Diseases 2015; 9(1): 50-5

Liver transplantation

Conditioning With Sevoflurane in Liver Transplantation: Results of a Multicenter Randomized Controlled Trial
Beck-Schimmer B J, Bonvini M, et al. Transplantation 2015 Aug;99(8):1606-12

Immunosuppression Modifications Based on an Immune Response Assay: Results of a Randomized, Controlled Trial
Ravaioli M, Flavia N, et al Transplantation 2015 Aug;99(8):1625-32

Tuberculosis Prophylaxis With Levofloxacin in Liver Transplant Patients is Associated With a High Incidence of Tenosynovitis: Safety Analysis of a Multicenter Randomized Trial
Torre-Cisneros J, San-Juan R, et al Clinical Infectious Diseases. 2015 Jun 1; 60(11): 1642-9

Renal Function in De Novo Liver Transplant Recipients Receiving Different Prolonged-Release Tacrolimus Regimens The DIAMOND Study
Trunecka P, Klempnauer J, et al American Journal of Transplantation. 2015 Jul; 15(7): 1843-54

Heart transplantation

The Effect of Everolimus Initiation and Calcineurin Inhibitor Elimination on Cardiac Allograft Vasculopathy in De Novo Recipients: One-Year Results of a Scandinavian Randomized Trial.
Arora S, Andreassen AK, et al. American Journal of Transplantation. 2015 Jul; 15(7): 1967-75

Randomized Pilot Trial of Gene Expression Profiling Versus Heart Biopsy in the First Year After Heart Transplant: Early Invasive Monitoring Attenuation Through Gene Expression Trial (EIMAGE)
Kobashigawa MD, Patel J, et al. Circulation. Heart Failure. 2015 May; 8(3): 557-64

Lung transplantation

A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation.
Corris PA, Ryan VA, et al. Thorax 2015;70(5):442-50.

Various organs

Increased osteoprotegerin predicts poor virological outcome during anticytomegalovirus therapy in solid organ transplant recipients
Ueland T, Rollag, H et al Transplantation 2015; 99(1):100-5.