Comparing glycaemic benefits of active versus passive lifestyle intervention in kidney allograft recipients (CAVIAR): a randomised controlled trial.Kuningas, K., Driscoll, J. et al. (2019).
Transplantation [record in progress].
This study investigates the benefit of active versus passive lifestyle intervention after kidney transplantation in preventing abnormal glycaemic control.
Kidney allograft recipients were randomly assigned to receive active intervention (lifestyle advice delivered by renal dietitians using behaviour change techniques) or a passive intervention (leaflet advice alone).
30 nondiabetic kidney transplant recipients with stable function between 3-24 months post transplantation.
Primary outcomes were assessed as the change in insulin secretion, insulin sensitivity and disposition index, 6 months post-transplantation. Secondary outcomes included patient-reported outcomes, cardio-metabolic parameters, clinical outcomes and safety endpoints.
This single-centre randomised controlled trial evaluated the benefit of active lifestyle intervention delivered by renal dieticians. The study was not blinded due to the nature of the intervention. The intervention did not improve any surrogate markers of glucose metabolism (insulin secretion, insulin sensitivity, disposition index). The study experienced 20% dropout, however it had been designed with an adequate power calculation to account for this degree of withdrawals.
ClinicalTrial.org - NCT02233491