Transplant Trial Watch

The Impact of Left Ventricular Assist Device Infections on Postcardiac Transplant Outcomes: A Systematic Review and Meta-Analysis.

Chahal, D., et al.

ASAIO Journal 2019; 65(8): 827-836


Aims
This systematic review aimed to investigate the relationship between left ventricular assist device (LVAD)-related infections and cardiac transplant outcomes.

Interventions
Electronic databases such as MEDLINE, EMBASE, Google Scholar, EBM Reviews – Cochrane Database of Systematic Reviews and EBM Reviews – Cochrane Central Register of Controlled Trials were searched up to September 2016. Two reviewers were involved in the study selection and data extraction process. The methodological quality of the included studies was assessed using the Newcastle–Ottawa Scale.

Participants
13 studies were included in the review

Outcomes
The main outcome of this study was all-cause mortality following cardiac transplant.

Follow-up
not applicable

CET Conclusions
The aim of the systematic review was to evaluate whether LVAD-related infections have an impact on survival after heart transplantation. A comprehensive bibliographic search was conducted and two independent reviewers screened all references, selected studies for inclusion and extracted data. The methodological quality of studies was assessed using the Newcastle-Ottawa scale and studies were scored as being of moderate to good quality. Thirteen studies reporting on 6,631 patients were included. Patients who had LVAD infections were younger, had a higher BMI and had received longer LVAD support. The primary outcome was posttransplant mortality and the pooled estimate showed a 30% increased risk of death for patients who had an LVAD infection, irrespective of the type of device (pulsatile or continuous flow).

Trial registration
not applicable

Funding source
Not reported