Transplant Trial Watch

Uromodulin to Osteopontin Ratio in Deceased Donor Urine is Associated with Kidney Graft Outcomes.

Mansour, S. G., et al.

Transplantation 2020 [record in progress].


Aims
The aim of this study was to examine the association of uromodulin (UMOD) to osteopontin (OPN) ratio in deceased donor urine with recipient graft outcomes.

Interventions
A cohort of deceased donors and recipients were randomly divided into a training dataset and a test dataset.

Participants
2340 kidney transplant recipients and 1298 donors.

Outcomes
The primary endpoints included death-censored graft failure (dcGF) and all-cause graft failure (GF). Secondary endpoints were estimated glomerular filtration rate (eGFR) at 6 months and delayed graft function (DGF).

Follow-up
4 years (median)

CET Conclusions
This study investigated the relationship between the uromodulin:osteopontin ratio in deceased donor urine, and clinical outcomes following renal transplant. The donors were randomly split into training and validation cohorts, and the authors identified a relationship between the UMOD:OPN ratio and risk of graft failure, DGF and 6-month eGFR. This is an interesting finding and may help with risk stratification in deceased donors. Exactly how it can be applied in clinical practice would need to be defined in prospective clinical studies. It may also have a role to play in assessment of kidneys during normothermic preservation.

Trial registration
ClinicalTrials.gov - NCT01848249

Funding source
Non-industry funded