Transplant Trial Watch

Association between day of the week and medication adherence among adolescent and young adult kidney transplant recipients.

Boucquemont, J., et al.

American Journal of Transplantation 2020; 20(1): 274-281.


Aims
This post-hoc analysis of the Teen Adherence in Kidney transplant Effectiveness of Intervention Trial (TAKEā€IT) aimed to investigate whether adolescent and young adult renal transplant patients had poorer medication adherence during weekends in comparison to weekdays.

Interventions
Participants in the TAKE-IT trial were randomly assigned to either the adherence-promoting intervention group, or the control group where adherence was not discussed.

Participants
138 kidney transplant patients aged 11 to 24 years.

Outcomes
The main outcomes of interest were the proportion of prescribed doses administered (taking adherence), and the proportion of prescribed doses administered within a period of 1 hour before to 2 hours after the dosing time prescribed (timing adherence).

Follow-up
12 months

CET Conclusions
This is a post-hoc analysis of the Teen Adherence in Kidney transplant Effectiveness of Intervention Trial (TAKE-IT) which showed that participants in the intervention arm had significantly greater odds of taking prescribed medications and taking medications at or near the prescribed time compared to the control group (https://www.transplantlibrary.com/article/29602631). The post-hoc analysis reviewed whether medication adherence differs by day of the week and included 138 adolescent and young adult kidney transplant recipients. Data showed that taking adherence (100% adherence) and on-time dosing (100% timing adherence) was less likely on weekends than weekdays but there was no difference by treatment group. The authors suggest that the change in routine between weekdays and weekends causes poor adherence on weekends.

Trial registration
ClinicalTrials.gov - NCT01356277

Funding source
Non-industry funded