Transplant Trial Watch

Allotransplantation of donor rectus fascia for abdominal wall closure in transplant patients: A systematic review.

Janssen, Y., et al.

Transplantation Reviews 2021; 35(4): 100634.


Aims
The aim of this study was to compare the feasibility, effectiveness and safety of vascularised versus nonvascularised rectus fascia allotransplantation (ATx) techniques in transplant patients.

Interventions
Databases including Pubmed, Embase and the Cochrane Library were used to search for relevant literature. Studies were assessed for eligibility by two independent reviewers. Three independent reviewers extracted data. The quality of the included studies were assessed using an adapted 10-item standardized checklist.

Participants
9 studies were included in the review.

Outcomes
Surgical site infection (SSI), sepsis, solid organ transplant (SOT) rejection, graft loss, fascial closure, skin closure, hernia formation and mortality.

Follow-up
N/A

CET Conclusions
This narrative systematic review explores the literature regarding the use of vascularised and non-vascularised rectus fascia transplantation to aid abdominal closure following intestinal or liver transplantation. The authors summarize the procurement and implantation techniques and outcomes from 9 articles reporting 74 cases. The review methodology is sound, and the report is clear and comprehensive. Clearly, the evidence is limited in both quantity and quality, with generally poor study design and reporting standards. None of the studies were prospective or compared techniques. Nonetheless, the article provides a good summary of the published evidence.

Trial registration
PROSPERO - CRD42018093923

Funding source
No funding received