Transplant Trial Watch

Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.

Nielsen, M. B., et al.

PLoS One 2021; 16(8): e0255930.


Aims
This post-hoc analysis of the randomised controlled CONTEXT trial examines whether higher levels of plasma free thiols as a marker of reduced oxidative stress is linked to better posttransplant outcomes.

Interventions
Participants in the CONTEXT trial were randomised to either the remote ischaemic conditioning (RIC) group or the sham-RIC group.

Participants
217 kidney transplant patients who participated in the CONTEXT trial.

Outcomes
Estimated time to a 50% reduction in plasma creatinine (tCr50), delayed graft function and measured glomerular filtration rate (mGFR).

Follow-up
12 months

CET Conclusions
This post-hoc analysis of samples from the CONTEXT RCT investigates the correlation between plasma free thiols (a marker of oxidative stress) and post-transplant outcomes. The authors find that free thiol levels at day 1 and 5 correlate significantly with 12-month measured GFR. Whilst the correlations are significant, the R-squared values are fairly low (around 0.2) suggesting limited predictive performance. It is therefore unclear how useful this would be as a tool in clinical practice, or indeed how measurement would help guide clinical care of patients to improve outcomes.

Trial registration
ClinicalTrials.gov - NCT01395719

Funding source
Non-industry funded