Transplant Trial Watch

Allograft discard risk index for heart transplantation.

Reul, R. M., Jr., et al.

Clinical Transplantation 2021 [record in progress].

The primary aim of this study was to develop a discard risk index (DSRI) for predicting heart allograft discard using donor factors.

The study cohort was randomly divided into a training cohort and a validation cohort.

72,652 heart donors.

The main outcome of interest was to create a DSRI based on the results of univariate and multivariate analyses.


CET Conclusions
The study developed a donor heart discard risk index (DSRI) using deceased donor data from UNOS. The DSRI aimed to predict the heart allograft discard using donor factors. The cohort of 72,652 donors was randomly split into a training and validation cohort. The two cohorts had similar demographics. A multivariable logistic regression analysis identified factors that were significantly associated with allograft discard, which included left ventricular ejection fraction, hepatitis B-virus core antibodies, diabetes and a donor age of >45y. The DSRI showed little correlation to mortality after transplantation. Data suggests that allografts with higher risk of discard could be used to increase donor heart utilisation without a significantly increased risk of mortality.

Trial registration

Funding source
Not reported