Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

December 2016

Kidney transplantation

Early conversion to prednisolone/everolimus as an alternative weaning regimen associates with beneficial renal transplant histology and function: the randomized-controlled MECANO trial.
Bemelman FJ, de Fijter JW, et al. American Journal of Transplantation 2016 [record in progress].

Controlled randomized study comparing the cardiovascular profile of everolimus with tacrolimus in renal transplantation.
Cruzado JM, Pascual J, et al. Transplant International 2016 [record in progress].

Effect of Fibrin Glue on the Incidence of Surgical Complications After Living-Related-Donor Kidney Transplantation: Results of a Randomized Clinical Trial.
Fuentes-Orozco C, Gonzalez-Mercado S, et al. Annals of Transplantation 2016; 21: 587-595.

Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model.
Jones-Hughes T, Snowsill T, et al. Health Technology Assessment (Winchester, England) 2016; 20(62): 1-594.

Remote ischemic conditioning on recipients of deceased renal transplants does not improve early graft function: A multicentre randomised, controlled clinical trial.
Krogstrup NV, Oltean M, et al. American Journal of Transplantation 2016 [record in progress].

A meta-analysis of renal outcomes in living kidney donors.
Li S, Huang Y, et al. Medicine 2016; 95(24): e3847.

Liver transplantation

Biliary complications following living donor hepatectomy
Braun HJ, Ascher NL, et al. Transplantation Reviews 2016; 30(4): 247-252.

Effect of sham feeding with gum chewing on postoperative ileus after liver transplantation - A randomized controlled trial.
Lee, H., C. W. Cho, et al. Clinical Transplantation 2016 [record in progress].

Lung transplantation

Longer Versus Shorter Duration of Rehabilitation Following Lung Transplantation: A Randomised Trial.
Fuller LM, Button B, et al. Archives of Physical Medicine and Rehabilitation 2016 [record in progress].

Various organs

Effects of structured education program on organ donor designation of nursing students and their families: A randomized controlled trial.
Murakami M, Fukuma S, et al. Clinical Transplantation 2016 [record in progress].