Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

March 2017

Kidney transplantation

Treatment With Ledipasvir-Sofosbuvir for 12 or 24 Weeks in Kidney Transplant Recipients With Chronic Hepatitis C Virus Genotype 1 or 4 Infection: A Randomized Trial.
Colombo M, Aghemo A, et al. Annals of Internal Medicine 2017; 166(2): 109-117.

Maximizing kidneys for transplantation using machine perfusion: from the past to the future: A comprehensive systematic review and meta-analysis.
Hameed AM, Pleass HC, et al. Medicine 2016; 95(40): e5083.

Results of a randomized controlled trial analyzing telemedically supported case management in the first year after living donor kidney transplantation - a budget impact analysis from the healthcare perspective.
Kaier K, Hils S, et al. Health Economics Review 2017; 7(1): 1.

Ramipril versus placebo in kidney transplant patients with proteinuria: A multicentre, double-blind, randomised controlled trial.
Knoll GA, Fergusson D, et al. The Lancet Diabetes and Endocrinology 2016; 4(4): 318-326.

Cyclosporine Sparing Effect of Enteric-Coated Mycophenolate Sodium in De Novo Kidney Transplantation.
Lee SH, Park JB, et al. Yonsei Medical Journal 2017; 58(1): 217-225.

Effect of moderately intense perioperative glucose control on renal allograft function: a pilot randomized controlled trial in renal transplantation.
Parekh J, Roll GR, et al. Clinical Transplantation 2016; 30(10): 1242-1249.

Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience.
Pretagostini R, Poli L, et al. Transplantation Proceedings 2016; 48 (2): 326-8.

Rabbit-ATG or basiliximab induction for rapid steroid withdrawal after renal transplantation (Harmony): an open-label, multicentre, randomised controlled trial.
Thomusch O, Wiesener M, et al. Lancet 2017; 388(10063): 3006-3016.

Heart transplantation

Long-term effects of high-intensity interval training in heart transplant recipients: A 5-year follow-up study of a randomized controlled trial.
Yardley M, Gullestad L, et al. Clinical Transplantation 2017; 31(1).

Various organs

Cancer Screening Recommendations for Solid Organ Transplant Recipients: A Systematic Review of Clinical Practice Guidelines.
Acuna SA, Huang JW, et al. American Journal of Transplantation 2017; 17(1): 103-114.