Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

November 2017

Kidney transplantation

De novo low-dose sirolimus versus mycophenolate mofetil in combination with extended-release tacrolimus in kidney transplant recipients: a multicentre, open-label, randomized, controlled, non-inferiority trial.
Huh KH, Lee JG, et al. Nephrology Dialysis Transplantation 2017; 32(8): 1415-1424.

Enhanced Recovery Open Versus Laparoscopic Left Donor Nephrectomy: a Randomized Controlled Trial.
Mansour AM, El-Nahas AR, et al. Urology 2017 [record in progress].

Aliskiren reduces albuminuria after kidney transplantation.
Tylicki L, Debska-Slizien AM, et al. Acta Biochimica Polonica 2017; 64(2): 221-226.

Limited Clinical Utility of Remote Ischemic Conditioning in Renal Transplantation: A Meta-Analysis of Randomized Controlled Trials.
Zhou C, Ge Y, et al. PLoS ONE 2017; 12(1): e0170729.

Liver transplantation

Everolimus is Associated With Less Weight Gain Than Tacrolimus 2 Years Following Liver Transplantation: Results of a Randomized Multicenter Study.
Charlton M, Rinella M, et al. Transplantation 2017; 15: 15.

Propofol post-conditioning alleviates hepatic ischaemia reperfusion injury via BRG1-mediated Nrf2/HO-1 transcriptional activation in human and mice.
Ge M, Chen H, et al. Journal of Cellular & Molecular Medicine 2017; 27: 27.

Therapies for Patients with Hepatocellular Carcinoma Awaiting for Liver Transplantation: a Systematic Review and Meta-analysis.
Kulik L, Heimbach JK, et al. Hepatology 2017; 31: 31.

Safety of Anti-TNF Treatment in Liver Transplant Recipients: A Systematic Review and Meta-analysis.
Westerouen van Meeteren MJ, Hayee B, et al. Journal of Crohn's & colitis 2017; 11(9): 1146-1151.

Various organs

Cancer recurrence after solid organ transplantation: A systematic review and meta-analysis.
Acuna SA, Huang JW, et al. Transplantation Reviews 2017; 10: 10.

The rate of brain death and organ donation in patients resuscitated from cardiac arrest: a systematic review and meta-analysis.
Sandroni C, D'Arrigo S, et al. Intensive Care Medicine 2016; 42(11): 1661-1671.