Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

October 2016

Kidney transplantation

Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplant Recipients: A Pilot, Randomized-Controlled Trial.
Kulkarni S, Kirkiles-Smith NC, et al. American Journal of Transplantation 2016 [record in progress].

Open-Label, Randomized Study of Transition From Tacrolimus to Sirolimus Immunosuppression in Renal Allograft Recipients.
Tedesco-Silva H, Peddi VR, et al. Transplantation Direct 2016; 2(4): e69.

Wound healing complications in kidney transplant recipients receiving everolimus.
Ueno P, Felipe C, et al. Transplantation 2016 [record in progress].

Multiple Renal Arteries in Kidney Transplantation: A Systematic Review and Meta-Analysis.
Zorgdrager M, Krikke C, et al. Annals of Transplantation 2016; 21: 469-478.

Liver transplantation

Results of the TOP Study: Prospectively Randomized Multicenter Trial of an Ex Vivo Tacrolimus Rinse Before Transplantation in EDC Livers.
Pratschke S, Arnold H, et al. Transplantation Direct 2016; 2(6): e76.

Impact of Preemptive Fibrinogen Concentrate on Transfusion Requirements in Liver Transplantation: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.
Sabate A, Gutierrez R, et al. American Journal of Transplantation 2016; 16(8): 2421-2429.

Systematic Review and Meta-Analysis of the Impact of Computed Tomography-Assessed Skeletal Muscle Mass on Outcome in Patients Awaiting or Undergoing Liver Transplantation.
van Vugt JLA, Levolger S, et al. American Journal of Transplantation 2016; 16(8): 2277-2292.

Lung transplantation

Ex Vivo Perfusion Treatment of Infection in Human Donor Lungs.
Nakajima D, Cypel M, et al. American Journal of Transplantation 2016; 16(4): 1229-1237.

Various organs

Renin-angiotensin system inhibitors linked to anemia: a systematic review and meta-analysis.
Cheungpasitporn W, Thongprayoon C, et al. Qjm 2015; 108(11): 879-884.

Effects of a Video on Organ Donation Consent Among Primary Care Patients: A Randomized Controlled Trial.
Thornton JD, Sullivan C, et al. Journal of General Internal Medicine 2016; 31(8): 832-839.