To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
June 2025
Kidney transplantation
Efficacy and Safety of Pegcetacoplan in Kidney Transplant Recipients With Recurrent Complement 3 Glomerulopathy or Primary Immune Complex Membranoproliferative Glomerulonephritis.
Bomback, A. S., et al. KI Reports 2025; 10(1): 87-98.
Urine Measurements of the Renin-Angiotensin System-Regulated Proteins Predict Death and Graft Loss in Kidney Transplant Recipients Enrolled in a Ramipril versus Placebo Randomized Controlled Trial.
Farkona, S., et al. Journal of Proteome Research 2025; 25(4): 2040-2052.
Phase 2, Randomized, Double-blind, Placebo-controlled Study of Fiztasovimab (NPC-21) for Kidney Transplant Recipients at High Risk of Cytomegalovirus Infection (LionHeart21).
Ichimaru, N., et al Transplantation 2024 [record in progress].
Results of a multicenter, randomized trial examining a new transition model for post-kidney transplant adolescents.
Kreuzer, M., et al. Scientific Reports 2025; 15(1): 11459.
Pilot Randomized Trial Exploring the Impacts of Deceased Donor Kidney Procurement Biopsies on Organ Evaluation and Transplant Outcomes.
Lentine, K. L., et al. (2025). Cureus 2025; 17(4): e81728.
Effectiveness of a Mobile Health System on Compliance With 2-Year Living Kidney Donor Follow-Up in the United States.
Thomas, A. G., et al. Clinical Transplantation 2026; 39(4): e70139.
Heart transplantation
Survival after heart transplants from circulatory-dead versus brain-dead donors: Meta-analysis of reconstructed time-to-event data.
Al-Tawil, M., et al. Transplantation Reviews 2025; 39(2): 100917.
Lung transplantation
Safety and efficacy of immunoguided prophylaxis for cytomegalovirus disease in low-risk lung transplant recipients in Spain: a multicentre, open-label, randomised, phase 3, noninferiority trial.
Paez-Vega, A., et al. The Lancet Regional Health. Europe 2025; 52: 101268.