Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

January 2017

Kidney transplantation

Infections in de novo kidney transplant recipients treated with the RANKL inhibitor denosumab.
Bonani M, Frey D, et al. Transplantation 2016 [record in progress]

A Comparison of Two Types of Rabbit Antithymocyte Globulin Induction Therapy in Immunological High-Risk Kidney Recipients: A Prospective Randomized Control Study.
Burkhalter F, Schaub S, et al. PLoS ONE 2016 [Electronic Resource] 11(11): e0165233.

The influence of warm ischemia elimination on kidney injury during transplantation - clinical and molecular study.
Kaminska D, Koscielska-Kasprzak K, et al. Scientific Reports 2016; 6: 36118.

Predictors and Moderators of Educational Interventions to Increase the Likelihood of Potential Living Donors for Black Patients Awaiting Kidney Transplantation.
Rodrigue JR, Paek MJ, et al. J Racial Ethn Health Disparities 2016 [record in progress].

ADHERE: Randomized controlled trial comparing renal function in de novo kidney transplant recipients receiving prolonged-release tacrolimus plus MMF or sirolimus.
Rummo OO, Carmellini M, et al. Transplant International 2016 [record in progress].

Liver transplantation

A systematic review and meta-analysis of donor ischaemic preconditioning in liver transplantation.
Robertson FP, Magill LJ, et al. Transplant International 2016; 29(11): 1147-1154.

Various organs

Correlates and Outcomes of Posttransplant Smoking in Solid Organ Transplant Recipients: A Systematic Literature Review and Meta-Analysis.
Duerinckx N, Burkhalter H, et al. Transplantation 2016; 100(11): 2252-2263.

Randomized Controlled Trials to Define Viral Load Thresholds for Cytomegalovirus Pre-Emptive Therapy.
Griffiths PD, Rothwell E, et al. PLoS One 2016; 11(9): e0163722.

Anticipated regret and organ donor registration: A randomized controlled trial.
O'Carroll RE, Shepherd L, et al. Health Psychology 2016; 35(11): 1169-1177.

The viability of transplanting organs from donors who underwent cardiopulmonary resuscitation: A systematic review.
West S, Soar J, et al. Resuscitation 2016; 108: 27-33.