Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

September 2016

Kidney transplantation

Failure of Calcineurin Inhibitor (Tacrolimus) weaning randomized trial in long-term stable kidney transplant recipients.
Dugast E, Soulillou JP, et al. American Journal of Transplantation 2016 [record in progress].

A Prospective Randomized, Comparative Trial of High-Dose Mizoribine Versus Mycophenolate Mofetil in Combination With Tacrolimus and Basiliximab for Living Donor Renal Transplant: A Multicenter Trial.
Ishida H, Takahara S, et al. Experimental and Clinical Transplantation 2016 [record in progress].

Comparison of the effect of co-trimoxazole and co-trimoxazole plus ciprofloxacin in urinary tract infection prophylaxis in kidney transplant patients.
Khorvash F, Mortazavi M, et al. Advanced Biomedical Research 2016; 5: 108.

A Steady-state Head-to-Head Pharmacokinetic Comparison Of all FK-506 (Tacrolimus) Formulations (ASTCOFF): An Open Label, Prospective, Randomized, Two Arm, Three Period Crossover Study.
Tremblay S, Nigro V, et al. American Journal of Transplantation 2016 [record in progress].

Liver transplantation

Conversion From Calcineurin to Mammalian Target of Rapamycin Inhibitors in Liver Transplantation: A Meta-Analysis of Randomized Controlled Trials.
Glover TE, Watson CJE, et al. Transplantation 2016; 100(3): 621-629.

Heart transplantation

Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis.
Li Y, Guo S, et al. Artificial Organs 2016; 40(5): 489-496.

Various organs

Depression and Anxiety as Risk Factors for Morbidity and Mortality After Organ Transplantation: A Systematic Review and Meta-Analysis.
Dew MA, Rosenberger EM, et al. Transplantation 2015; 100(5): 988-1003.

Randomized Controlled Trial of a Computer-Based Education Program in the Home for Solid Organ Transplant Recipients: Impact on Medication Knowledge, Satisfaction, and Adherence.
Harrison JJ, Badr S, et al. Transplantation 2016 [record in progress].

Randomised, Double Blind, Controlled Trial of the Provision of Information about the Benefits of Organ Donation during a Family Donation Conversation.
Philpot SJ, Aranha S, et al. PLoS ONE 2016 [Electronic Resource] 11(6): e0155778.