About Us

Simon Knight

Simon Knight

Co-Director

[email protected]

Simon undertook his undergraduate studies at Corpus Christi College, Cambridge, gaining a BA in medical science in 2000 before studying clinical medicine at Addenbrooke's Hospital, Cambridge . He qualified as a doctor in 2002, and having completed his pre-registration year moved to Nottingham for his Basic Surgical Training. He completed his MRCS in December 2005 and moved to Oxford in May 2006 to take up a position as a clinical research fellow in transplant surgery, during which time he completed his Master of Surgery (MChir) thesis with the University of Cambridge. On returning to higher surgical training he remained on the staff of the CET as a consultant during his time as an NIHR Academic Clinical Lecturer.

Simon has now taken up post as a Senior Clinical Research fellow and Honorary Consultant Transplant Surgeon at the Oxford Transplant Centre. Following Peter Morris' retirement from the CET in July 2016, he has now taken on the role of Co-Director with Liset Pengel.

During his time at the CET, Simon has performed a number of systematic reviews relating to the optimisation of immunosuppressive therapies. These include therapeutic drug monitoring and steroid sparing regimens. A number of these reviews have been published in peer reviewed journals and presented as national and international conferences. His work on steroid sparing regimens won the 2009 clinical Medawar medal from the British Transplant Society. The work performed during his time as a research fellow was accepted as a thesis for the degree of Master of Surgery at Cambridge University, and awarded the MChir distinction prize and Sir Walter-Langdon Brown prize.

Simon is now involved in a number of review projects with the CET, supervising both academic foundation trainees and DPhil candidates. His university role as a Senior Research Fellow is affording him more time to pursue an interest in clinical trial design, and he is coinvestigator in a number of clinical trials including COPE, SONAR, PLUS, NKP-1 and TARGET.

Outside of medicine Simon has an interest in technology and computers, with considerable experience in web design.

Publications

Boffa C, Ceresa CDL, Vig S, Knight SR, Royston E, Quiroga I, Sinha S. Zero tolerance to sexual harassment in surgical training in the UK. Br J Surg. 2021 Oct 23;108(10):e345-e346 [PMID:34428281]

Knight SR. The Value of Systematic Reviews and Meta-Analyses in Surgery. Eur Surg Res. 2021 Oct 28:1-8. [PMID:34710877]

De Beule J, Vandendriessche K, Pengel LHM, Bellini MI, Dark JH, Hessheimer AJ, Kimenai HJAN, Knight SR, Neyrinck AP, Paredes D, Watson CJE, Rega F, Jochmans I. A systematic review and meta-analyses of regional perfusion in donation after circulatory death solid organ transplantation. Transplant International 2021 [record in progress] [PMID:34570380]

Husen P, Boffa C, Jochmans I, Krikke C, Davies L, Mazilescu L, Brat A, Knight S, Wettstein D, Cseprekal O, Banga N, Bellini MI, Szabo L, Ablorsu E, Darius T, Quiroga I, Mourad M, Pratschke J, Papalois V, Mathe Z, Leuvenink HGD, Minor T, Pirenne J, Ploeg RJ, Paul A. Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant: A Randomized Clinical Trial. JAMA Surg. 2021 Apr 21:e210949. [PMID:33881456]

Guzzi F, Knight SR, Ploeg RJ, Hunter JP. A systematic review to identify whether perfusate biomarkers produced during hypothermic machine perfusion can predict graft outcomes in kidney transplantation. Transpl Int. 2020 Jun;33(6):590-602. [PMID:32031281]

Jochmans I, Brat A, Davies L, Hofker HS, van de Leemkolk FEM, Leuvenink HGD, Knight SR, Pirenne J, Ploeg RJ; COMPARE Trial Collaboration and Consortium for Organ Preservation in Europe (COPE). Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial. Lancet. 2020 Nov 21;396(10263):1653-1662. [PMID:33220737]

Knight SR, Thorne A, Lo Faro ML. Donor-specific Cell-free DNA as a Biomarker in Solid Organ Transplantation. A Systematic Review. Transplantation. 2019; 103(2):273-283. [PMID:30308576]

Ceresa CDL, Nasralla D, Watson CJE, Butler AJ, Coussios CC, Crick K, Hodson L, Imber C, Jassem W, Knight SR, Mergental H, Ploeg RJ, Pollok JM, Quaglia A, Shapiro AMJ, Weissenbacher A, Friend PJ. Transient Cold Storage Prior to Normothermic Liver Perfusion May Facilitate Adoption of a Novel Technology. Liver Transpl. 2019 Oct;25(10):1503-1513. [PMID:31206217]

O'Callaghan JM, Knight SR. Noninvasive biomarkers in monitoring kidney allograft health. Curr Opin Organ Transplant. 2019; 24(4):411-415. [PMID:31145158]

Knight SR. Routine adherence monitoring after renal transplantation. Transpl Int. 2019; 32(6):600-602. [PMID:30825238]

Richards J, Hossain M, Summers D, Slater M, Bartlett M, Kosmoliaptsis V, Wilson EC, Lagaac R, Sidders A, Foley C, Laing E, Hopkins V, Fitzpatrick-Creamer C, Hudson C, Thomas H, Turner S, Tambyraja A, Somalanka S, Hunter J, Dutta S, Lawman S, Salter T, Aslam M, Bagul A, Sivaprakasam R, Smith G, Moinuddin Z, Knight S, Gibbs P, Motallebzadeh R, Barnett N, Pettigrew G; SONAR trial group. Surveillance arterioveNous fistulAs using ultRasound (SONAR) trial in haemodialysis patients: a study protocol fo

Mulley WR, Dendle C, Ling JEH, Knight SR. Does vaccination in solid-organ transplant recipients result in adverse immunologic sequelae? A systematic review and meta-analysis. J Heart Lung Transplant. 2018; S1053-2498(18) 31382-2. [PMID:29609844]

Hunter JP, Knight SR, Inston N, Ridway D, Tavakoli A, Suttie S, Kingsmore D, Brown T, Sultan S, Gilbert J. The United Kingdom and Ireland experience of the Haemodialysis Reliable Outflow graft for vascular access. J Vasc Access 2018. Epub ahead of print. [PMID:29681225]

Knight SR, Thorne A, Faro MLL. Donor-specific Cell-Free DNA as a Biomarker in Solid Organ Transplantation. A Systematic Review. Transplantation 2018. Epub ahead of print. [PMID:30308576]

Nasralla D, Coussios CC, Mergental H, Akhtar MZ, Butler AJ, Ceresa CDL, Chiocchia V, Dutton SJ, García-Valdecasas JC, Heaton N, Imber C, Jassem W, Jochmans I, Karani J, Knight SR, Kocabayoglu P, Malagò M, Mirza D, Morris PJ, Pallan A, Paul A, Pavel M, Perera MTPR, Pirenne J, Ravikumar R, Russell L, Upponi S, Watson CJE, Weissenbacher A, Ploeg RJ, Friend PJ; Consortium for Organ Preservation in Europe. A randomized trial of normothermic preservation in liver transplantation. Nature. 2018 May;5 [PMID:29670285]

Knight SR, Cao KN, South M, Hayward N, Hunter JP, Fox J. Development of a Clinical Decision Support System for Living Kidney Donor Assessment Based on National Guidelines. Transplantation. 2018 Oct;102(10):e447-e453. [PMID:30028418]

Ayaz-Shah AA, Hussain S, Knight SR. Do clinical trials reflect reality? A systematic review of inclusion/exclusion criteria in trials of renal transplant immunosuppression. Transpl Int. 2018 Apr;31(4):353-360. [PMID:29274240]

O'Donoghue KJM, Pengel LHM, Ayaz-Shah AA, Knight SR. Do the Online Materials Provided by United Kingdom Renal Transplant Centres Adequately Answer Questions asked by Transplant Recipients, Patients on the Transplant Waiting List, Carers and Live Kidney Donors? (Poster presentation at the TTS Congress, Madrid, Spain, 1-5 July, 2018).

OʼDonoghue KJM, Reed RD, Knight SR, O'Callaghan JM, Ayaz-Shah AA, Hassan S, Weissenbacher A, Morris PJ, Pengel LHM. Critical Appraisal of International Clinical Practice Guidelines in Kidney Transplantation Using the Appraisal of Guidelines for Research and Education (AGREE) II Tool: A Systematic Review. Transplantation 2018; 102(9):1419-1439. [PMID:29787524]

O’Donoghue KJM, Reed RD, Knight SR, O’Callaghan JM, Ayaz-Shah AA, Hassan S, Morris PJ, Pengel LHM. Systematic review of clinical practice guidelines in kidney transplantation. BJS Open 2017; 1(4): 97–105. [PMID:29951611]

Macklin PS, Morris PJ, Knight SR. A systematic review of the use of rituximab for the treatment of antibody-mediated renal transplant rejection. Transplantation Reviews 2017; 31(2): 87-95. [PMID:28187998]

Sautenet B, Tong A, Manera KE, Chapman JR, Warrens AN, Rosenbloom D, Wong G, Gill J, Budde K, Rostaing L, Marson L, Josephson MA, Reese PP, Pruett TL, Hanson CS, O'Donoghue D, Tam-Tham H, Halimi JM, Shen JI, Kanellis J, Scandling JD, Howard K, Howell M, Cross N, Evangelidis N, Masson P, Oberbauer R, Fung S, Jesudason S, Knight S, Mandayam S, McDonald SP, Chadban S, Rajan T, Craig JC. Developing Consensus-Based Priority Outcome Domains for Trials in Kidney Transplantation: A Multinational Delphi [PMID:28738403]

Ceresa CD, Nasralla D, Knight S, Friend PJ. Cold storage or normothermic perfusion for liver transplantation: probable application and indications. Curr Opin Organ Transplant 2017; 22(3): 300-305. [PMID:28301388]

Ayaz-Shah AA, Hussein S, Knight SR. Do clinical trials reflect reality? A systematic review of inclusion/exclusion criteria in trials of renal transplant immunosuppression. 2017 (Accepted poster presentation at the ESOT Congress, Barcelona, Spain, 24- 27 September, 2017)

O'Donoghue KJM, Reed RD, Knight SR, O'Callaghan JM, Ayaz-Shah AA, Hassan S, Weißenbacher A, Morris PJM, Locke J, Pengel LHM. Critical appraisal of international clinical practice guidelines in kidney transplantation using the Appraisal of Guidelines for Research and Education (AGREE) II tool: A systematic review. 2017 (Accepted Abstract at the BTS Congress, Yorkshire, UK, 1-3 March, 2017).

Knight SR. Intra-patient variability in tacrolimus exposure - a useful tool for clinical practice? Transpl Int. 2016; 29(11):1155-1157 [PMID:27283231]

O'Donoghue KJM, Reed RD, Knight SR, O'Callaghan JM, Morris PJ, Locke J, Pengel LHM. Critical Appraisal of Clinical Practice Guidelines in Kidney Transplantation using the Appraisal of Guidelines for Research and Education (AGREE) II tool: A Systematic Review. 2016. (Poster presentation at the BTS Congress, Glasgow, UK, 24-26 February, 2016).

Knight SR, Morris PJ, Schneeberger S, Pengel LH. Trial design and end points in clinical transplant research. Transpl Int. 2016;29(8):870-9 [PMID:26749215]

Jochmans I, Akhtar MZ, Nasralla D, Kocabayoglu P, Boffa C, Kaisar M, Brat A, O'Callaghan J, Pengel LH, Knight S, Ploeg R. Past, present and future of dynamic kidney and liver preservation and resuscitation. Am J Transplant. 2016; 16(9):2545-55. [PMID:26946212]

O'Callaghan JM, Knight SR, Morgan RD, Morris PJ. A National Registry Analysis of Kidney Allografts Preserved With Marshall's Solution in the United Kingdom. Transplantation. 2016 Nov;100(11):2447-2452. [PMID:26760566]

Knight SR, Hussain S. Variability in the reporting of renal function endpoints in immunosuppression trials in renal transplantation: time for consensus? Clin Transplant. 2016;30(12):1584-1590. [PMID:27740730]

Knight SR, Metcalfe L, O’Donoghue K, Ball ST, Beale A, et al. (2016) Defining Priorities for Future Research: Results of the UK Kidney Transplant Priority Setting Partnership. PLoS ONE 11(10): e0162136

Hussain S, Knight SR. Quality and consistency of outcome reporting in clinical trials of immunosuppression in renal transplantation. Clinical Transplantation. 2016;30(11):1440-1448. [PMID:27582408]

Macklin PS, Morris PJ, Knight SR. A systematic review of the use of rituximab as induction therapy in renal transplantation. Transplant Rev. 2015; 29(2):103-8. [PMID:25555541]

Pengel LHM, Knight SK, Morris PJ. Transplant Library - the definitive resource of high quality evidence in solid organ. RCS Annual Day 2014 and SITU’s Launch, March 26, 2014, University of Oxford, UK.

O'Callaghan J, Knight S, Morgan R, Morris P. A national registry analysis of kidney allograft presentation with Marshall's Solution in the United Kingdom. (Oral at the British Transplantation Society, Glasgow 2014)

O'Callaghan J, Knight S, Morgan R, Morris P. A national registry analysis of kidney allograft preservation with Marshall's Solution in the United Kingdom (Poster presentation at the World Transplant Congress, San Francisco, 2014)

Evans JDW, Morris PJ and Knight SR. Antifungal Prophylaxis In Liver Transplantation: A Systematic Review And Network Meta-Analysis. American Journal of Transplantation 2014;14(12):2765-76 [PMID:25395336]

Knight SR. Social media and online attention as an early measure of the impact of research in solid organ transplantation. Transplantation. 2014 Sep 15;98(5):490-6 [PMID:25061904]

MacKlin P, Morris PJ and Knight SR. A Systematic Review of the Use of Rituximab for Desensitization in Renal Transplantation. Transplantation 2014; 98(8):794-805 [PMID:25321163]

Knight S, Vogel T and Friend P. Pancreas Transplantation. Surgery 2014; 32(7): 383–388

Som R, Morris PJ and Knight SR. Graft Vessel Disease Following Heart Transplantation: A Systematic Review of the Role of Statin Therapy. World Journal of Surgery 2014; DOI:10.1007/s00268-014-2543-x [PMID:24700094]

O'Callaghan JM, Morgan RD, Knight SR and Morris PJ. The Effect of Preservation Solutions for Storage of Liver Allografts on Transplant Outcomes: A Systematic Review and Meta-analysis. Annals of Surgery. 2014 Jul; 260(1):46-55 [PMID:24374537]

O'Callaghan J, Morgan R, Knight S, Morris P. Liver allograft preservation fluids: A Systematic review and Meta-Analysis. (Poster presentation at the European Society for Organ Transplantation, Vienna 2013)

Pengel L, Knight S, Emin A, O'Callaghan J, Van der Meulen J, Papalois V, Morris P. How to teach evidence-based practice skills in 1.5 days: The Evidence in Transplantation (EVIT) Course. (Poster presentation at the European Society for Organ Transplantation, Vienna 2013)

O'Callaghan JM, Morgan RD, Knight SR, Morris PJ. Systematic review and meta-analysis of hypothermic machine perfusion versus static cold storage for kidney allografts on transplant outcomes. British Journal of Surgery. 2013 Jul; 100(8):991-1001. [PMID:23754643]

O'Callaghan J, Morgan R, Knight S, Morris P. Systematic reviews of alemtuzumab in renal transplantation. Transplant Immunology. March 2013; 28 (2): 71. [PMID:23352935]

Pengel LHM, Knight S, Emin A, O’Callaghan J, Van der Meulen J, Papalois V, Morris PJ. How to teach evidence-based skills in 1.5 days: the Evidence in Transplantation (EVIT) Course. 16th Congress of the European Society for Organ Transplantation, September 8-11, 2013, Vienna, Austria

Macklin P,Knight S, Morris P. A systematic review of rituximab as desensitisation therapy in renal transplantation. (Poster presentation at the Joint British Transplantation Society and Renal Association Congress, Bournemouth, March 2013)

O'Callaghan J, Morgan R, Knight S, Morris P.Preservation solutions for static cold storage of liver allografts: A systematic review and meta-analysis. 16th Annual Congress of the British Transplantation Society, Bournemouth, 2013.

Knight SR, Pengel LHM, Morris PJ. Chapter 42: Evidence in Transplantation in Kidney Transplantation: Principles and Practice. 7th edition. Eds. P. J. Morris and Stuart J Knechtle, Elsevier, Philadelphia. p729- 736

Knight SR. Chapter 16: Steroids in Kidney Transplantation: Principles and Practice. 7th edition. Eds. P. J. Morris and Stuart J Knechtle, Elsevier, Philadelphia. p221-230

O'Callaghan J, Morgan R, Knight S, Morris P. Liver allograft preservation fluids: A systematic review and meta-analysis. Transplant International. 2013; 26(Supp s2):332

Pengel LHM, Knight S, Emin A, O'Callaghan J, Van der Meulen J, Papalois V, Morris P. How to teach evidence-based practice skills in 1.5 days: the Evidence in Transplantation (EVIT) course. Transplant International. 2013; 26(Supp s2);192

Morgan R, O'Callaghan J, Knight S, Morris P. Alemtuzumab induction therapy in kidney transplantation: A Systematic Review and Meta-Analysis. Transplantation. 2012; 94(10S):972

Morgan RD*, O’Callaghan JM, Knight SR, Morris PJ. Alemtuzumab induction therapy in kidney transplantation: a systematic review and meta-analysis. 24th International Congress of The Transplantation Society, Berlin, Germany. * presenting author

O'Callaghan J, Morgan R, Knight S, Morris P. Hypothermic machine preservation in comparison with static cold storage for kidney allografts: A Systematic review and Meta-Analysis. Transplantation. 2012; 94(10S):277

O’Callaghan J, Morgan R, Knight S, Morris P. Hypothermic machine preservation in comparison with static cold storage for kidney allografts. The Transplantation Society Congress, Berlin 2012

Morgan RD, O'Callaghan JM, Knight SR, Morris PJ. Alemtuzumab induction therapy in kidney transplantation: a systematic review and meta-analysis. Transplantation 2012; 93(12): 1179-1188 [PMID:22660659]

O'Callaghan JM, Knight SR, Morgan RD, Morris PJ. Preservation solutions for static cold storage of kidney allografts: a systematic review and meta-analysis. American Journal of Transplantation 2012; 12(4): 896-906. [PMID:22221739]

Knight SR, Morris PJ. Steroid sparing protocols following nonrenal transplants; the evidence is not there. A systematic review and meta analysis. Transplant International 2011; 24(12): 1198-1207 [PMID:21923805]

Knight SR, Morris PJ. Steroid avoidance or withdrawal in renal transplantation. Transplantation 2011; 91(5):e25; author reply e26-7 [PMID:21336081]

O’Callaghan J, Knight S, Morgan R, Morris P. Preservation solutions for static cold storage of kidney allografts. Oral- European Society of Organ Transplantation, Glasgow 2011

Knight SR, Morris PJ. Interaction between maintenance steroid dose and the risk/benefit of steroid avoidance and withdrawal regimens following renal transplantaion. Transplantation 2011; 92(11): e63-4

O'Callaghan J, Morgan R, Knight S, Morris P. Preservation solutions for static cold storage of kidney allografts: A Systematic Review and Meta-Analysis. Transplant International. 2011; 24(s2):204

Knight SR and Morris PJ. Steroid avoidance or withdrawal following renal transplantation increases the risk of acute rejection but decreases cardiovascular risk. A meta-analysis. Transplantation 2010. Jan 15; 89 (1): 1-14 [PMID:20061913]

Currie AC, Knight SR and Morris PJ. Tuberculosis in Renal Transplant Recipients: The Evidence for Prophylaxis. Transplantation 2010; 90(7): 695-704 [PMID:20647975]

Knight SR, Russell NK, Barcena L, Morris PJ. Mycophenolate mofetil decreases acute rejection and may improve graft survival. A systematic review. Transplantation 2009;87(6):785-94 [PMID:19300178]

Knight SR. Optimisation of Immunosuppressive drug therapy in Transplant Recipients. MCh. Thesis, University of Cambridge. 2009.

Knight SR and Morris PJ. In response to: Benefit of neoral C2 monitoring in de novo cardiac transplant recipients receiving basiliximab induction. Transplantation 2008 Sep 27;86(6):885 [PMID:18813115]

Knight SR and Morris PJ. Does the evidence support the use of Mycophenolate Mofetil therapeutic drug monitoring in clinical practice? A systematic review. Transplantation 2008; 85(12): 1675-1685. [PMID:18580456]

Russell NK, Knight SR and Morris PJ. Cyclosporine in Kidney Transplantation: Principles and Practice 6th Edition (eds. Morris PJ & Knechtle S), 2008: p234

Knight SR, Morris PJ. Azathioprine and Steroids in Kidney Transplantation: Principles and Practice 6th Edition (eds. Morris PJ & Knechtle S), 2008: p220

Knight SR and Morris PJ. The clinical benefits of cyclosporine C2-level monitoring: a systematic review. Transplantation 2007; 83(12):1525-35 [PMID:17589331]

Knight, SR, Friend PJ, Morris PJ (2007) Role of transplantation in the management of hepatic malignancy. Brit J. Surg. 2007; 94(11) : 1319-30 [PMID:17939138]