Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

January 2021

Kidney transplantation

Reporting and handling of missing participant data in systematic reviews of kidney transplant studies.
Budhiraja, P., et al. Transplantation 2020 [record in progress].

Risk Factors for 1-Year Graft Loss After Kidney Transplantation: Systematic Review and Meta-Analysis.
Foroutan, F., et al. Clinical Journal of the American Society of Nephrology 2019; 14(11): 1642-1650.

Randomized clinical trial to determine the effectiveness of CO-oximetry and anti-smoking brief advice in a cohort of kidney transplant patients who smoke.
Seijo-Bestilleiro, R., et al. International Journal of Medical Sciences 2020; 17(17): 2673-2684.

Epitope load identifies kidney transplant recipients at risk of allosensitization following minimization of immunosuppression.
Snanoudj, R., et al. Kidney International 2019; 95(6): 1471-1485.

Comparison of Surgical Techniques in Living Donor Nephrectomy: A Systematic Review and Bayesian Network Meta-Analysis.
Xiao, Q., et al. Annals of Transplantation 2020; 25: e926677.

Liver transplantation

Sirolimus Prolongs Survival after Living Donor Liver Transplantation for Hepatocellular Carcinoma Beyond Milan Criteria: A Prospective, Randomised, Open-Label, Multicentre Phase 2 Trial.
Lee, K. W., et al. Journal of Clinical Medicine 2020; 9(10): 12.

Multicenter, Double-Blind, Randomized Trial of Emricasan in Hepatitis C Treated Liver Transplant Recipients with Residual Fibrosis or Cirrhosis.
Weinberg, E. W., et al Liver Transplantation 2020 [record in progress].

Various organs

Use of Direct-acting Oral Anticoagulants in Solid Organ Transplantation: A Systematic Review.
Bixby, A. L., et al. Pharmacotherapy 2020 [record in progress].

Effectiveness of eHealth interventions for improving medication adherence of organ transplant patients: A systematic review and meta-analysis.
Lee, H., et al. PLoS ONE [Electronic Resource] 2020; 15(11): e0241857.