Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

June 2018

Kidney transplantation

Antibiotics for asymptomatic bacteriuria in kidney transplant recipients.
Coussement J, Scemla A, et al. Cochrane Database of Systematic Reviews 2018.

A Phase I/II, Double-Blind, Placebo-Controlled Study Assessing Safety and Efficacy of C1 Esterase Inhibitor for Prevention of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients.
Jordan SC, Choi J, et al. American Journal of Transplantation 2018; 10: 10.

Differential T Cell Signaling Pathway Activation by Tacrolimus and Belatacept after Kidney Transplantation: Post Hoc Analysis of a Randomised-Controlled Trial.
Kannegieter NM, Hesselink DA, et al. Scientific Reports 2017; 7(1): 15135.

The benefits of hypothermic machine preservation and short cold ischemia times in deceased donor kidneys.
Kox J, Moers C, et al. Transplantation 2018 [record in progress].

Incidence of nonmelanoma skin cancer in renal transplant recipients: A systematic review and meta-analysis.
Matinfar M, Shahidi S, et al. Journal of Research in Medical Sciences 2018; 23(14).

Treatment of chronic antibody mediated rejection with intravenous immunoglobulins and rituximab: A multicenter, prospective, randomized, double-blind clinical trial.
Moreso F, Crespo M, et al. American Journal of Transplantation 2018; 18(4): 927-935.

Liver transplantation

Both sarcopenia and frailty determine suitability of patients for liver transplantation-A systematic review and meta-analysis of the literature.
Kahn J, Wagner D, et al. Clinical Transplantation 2018 [record in progress]: e13226.

Lung transplantation

Adherence to Mediterranean and low-fat diets among heart and lung transplant recipients: a randomized feasibility study.
Entwistle TR, Green AC, et al. Nutrition Journal 2018; 17(1): 22.

Montelukast for bronchiolitis obliterans syndrome after lung transplantation: A randomized controlled trial.
Ruttens D, Verleden SE, et al. PLoS ONE 2018 [Electronic Resource] 13(4): e0193564.

Various organs

Implementation of a Web-Based Organ Donation Educational Intervention: Development and Use of a Refined Process Evaluation Model.
Redmond N, Harker L, et al. Journal of Medical Internet Research 2017; 19(11): e396.