To keep the transplantation community informed about recently published evidence in organ transplantation the Centre for Evidence in Transplantation has developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
October 2025
Kidney transplantation
Comparison of intraoperative and postoperative outcomes between open and robotic-assisted kidney transplantation: a meta-analysis and systematic review
Chen, Y., et al. J Robot Surg. 2025 Sep 10;19(1):584.
Renal resistance during hypothermic machine perfusion: A scoping review of variability and determinants, with a meta-analysis of predictive value for transplant outcomes.
Fonseca Buitrago, L., et al. Transplant Rev (Orlando). 2025 Jul 17;39(4):100956.
A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients
Mulley, W.R., et al. Kidney Int. 2025 Sep;108(3):470-480
Evaluation of a national digital pre-implantation biopsy service for deceased-donor kidney transplantation in the UK (Pithia trial); a stepped-wedge cluster randomised registry trial
Summer, D. M., et al. Lancet Reg Health Eur. 2025 Jul 22;56:101390.
Liver transplantation
Higher vs standard mean arterial pressure target in the immediate postoperative period of liver transplantation to prevent acute kidney injury: A randomized clinical trial (LIVER-PAM)
de Moura Pedro, R. A., et al. Am J Transplant. 2025 Aug 5 [record in progress]
Ischemia-free liver transplantation alleviates post-transplant myocardial injury and pulmonary complication: a post hoc analysis from IFLT-DBD trial.
Shen, Y., et al. Int J Surg. 2025 Aug 1;111(8):5288-5297.
Night-Time Chronotherapy with Methylprednisolone Prevents an Acute Rejection in Pediatric Patients with Liver Transplantation: A Randomized Clinical Trial.
Ushijima, K., et al. Clin Pharmacol Ther. 2025 Aug;118(2):386-393.
Various organs
Real-world effectiveness and tolerability of post solid organ transplant patients with CMV switching from valganciclovir treatment to maribavir: analysis using lab-linked claims data in the United States.
Expert Rev Anti Infect Ther. 2025 Aug;23(8):653-662. Rajagopalan, K., et al.
The experiences of clinical staff approaching families for organ donation consent: A systematic review and thematic synthesis of qualitative studies.
Pengel, L. H. M., et al. Transplant Rev (Orlando). 2025 Jul;39(3):100935.
Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and meta-analysis.
Sandroni, C., et al. Resuscitation. 2025 Aug;213:110654