Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

November 2020

Kidney transplantation

Effects of Desflurane and Sevoflurane anesthesia on regulatory T cells in patients undergoing living donor kidney transplantation: a randomized intervention trial.
Chutipongtanate, A., et al. BMC Anesthesiology 2020; 20(1): 215.

Glucose-lowering agents for treating pre-existing and new-onset diabetes in kidney transplant recipients.
Lo, C., et al. Cochrane Database of Systematic Reviews 2020; 8: CD009966.

Uromodulin to Osteopontin Ratio in Deceased Donor Urine is Associated with Kidney Graft Outcomes.
Mansour, S. G., et al. Transplantation 2020 [record in progress].

Postoperative outcomes of kidney transplant recipients undergoing non-transplant-related elective surgery: a systematic review and meta-analysis.
Palamuthusingam, D., et al. BMC Nephrology 2020; 21(1): 365.

Efficacy of ultrasound guided quadratus lumborum block as postoperative analgesia in renal transplantation recipients: A randomised double blind clinical study.
Sindwani, G., et al. Indian Journal of Anaesthesia 2020; 64(7): 605-610.

Liver transplantation

mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors.
Schnitzbauer, A. A., et al. Annals of Surgery 2020 [record in progress].

Heart transplantation

High-intensity interval training and health-related quality of life in de novo heart transplant recipients - results from a randomized controlled trial.
Rolid, K., et al. Health & Quality of Life Outcomes 2020; 18(1): 283.

Various organs

A Clustered Randomized Trial Informing Patients on Dialysis About Their Ability to Donate Organs and Tissues.
Andrews, A. M., et al. Progress in Transplantation 2020; 30(3): 220-227.

A Systematic Review of Donor Serum Sodium Level and Its Impact on Transplant Recipients.
Basmaji, J., et al. International Journal of Organ Transplantation Medicine 2020; 11(2): 43-54.

Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients.
Chan, S., et al. Cochrane Database of Systematic Reviews 2020; 8: CD013209.