Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.


August 2022

Kidney transplantation

Risks for donors associated with living kidney donation: meta-analysis.
Bellini, M. I., et al. British Journal of Surgery 2022 [record in progress].

The impact of mTOR inhibitors in the regression of left ventricular hypertrophy in elderly kidney transplant recipients.
David-Neto, E., et al. Clinical Transplantation 2022 [record in progress].

Enhanced Humoral Immune Response After COVID-19 Vaccination in Elderly Kidney Transplant Recipients on Everolimus Versus Mycophenolate Mofetil-containing Immunosuppressive Regimens.
de Boer, S. E., et al. Transplantation 2022 [record in progress].

Immunogenicity and safety of double dosage of pneumococcal vaccines in adult kidney transplant recipients and waiting list patients: A non-blinded, randomized clinical trial.
Larsen, L., et al. Vaccine 2022; 40(28): 3884-3892

Effect of Perioperative Dexmedetomidine on Delayed Graft Function Following a Donation-After-Cardiac-Death Kidney Transplant: A Randomized Clinical Trial.
Shan, X. S., et al. JAMA Network Open 2022; 5(6): e2215217.

Liver transplantation

Hypothermic Oxygenated Perfusion in Extended Criteria Donor Liver Transplantation - A Randomized Clinical Trial.
Ravaioli, M., et al. American Journal of Transplantation 2022 [record in progress].

Heart transplantation

Cardiovascular Magnetic Resonance for Rejection Surveillance After Cardiac Transplantation.
Anthony, C., et al. Circulation 2022; 145(25): 1811-1824.

Lung transplantation

Prone ex vivo lung perfusion protects human lungs from reperfusion injury.
Niikawa, H., et al. Artificial Organs 2022 [record in progress].

The effect of early tracheal extubation combined with physical training on pulmonary rehabilitation of patients after lung transplantation: a randomized controlled trial.
Wu, T., et al. Journal of Thoracic Disease 2022; 14(4): 1120-1129.

Other

Pancreas Transplantation for Type 2 Diabetes: A Systematic Review, Critical Gaps in the Literature, and a Path Forward.
Amara, D., et al. (2022). Transplantation 2022 [record in progress].