Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.


October 2021

Kidney transplantation

A systematic review and meta-analysis of COVID-19 in kidney transplant recipients: Lessons to be learned.
Kremer, D., et al. American Journal of Transplantation 2021 [record in progress].

Elevated plasma free thiols are associated with early and one-year graft function in renal transplant recipients.
Nielsen, M. B., et al. PLoS One 2021; 16(8): e0255930.

Significant hospitalization cost savings to the payer with a pharmacist-led mobile health intervention to improve medication safety in kidney transplant recipients.
Taber, D. J., et al. American Journal of Transplantation 2021 [record in progress].

Liver transplantation

Hypothermic Oxygenated Machine Perfusion (HOPE) Reduces Early Allograft Injury and Improves Post-Transplant Outcomes in Extended Criteria Donation (ECD) Liver Transplantation from Donation After Brain Death (DBD): Results from a Multicenter Randomized Controlled Trial (HOPE ECD-DBD).
Czigany, Z., et al. Annals of Surgery 2021 [record in progress]

Renal Protective Effect of Everolimus in Liver Transplantation: A Prospective Randomized Open-Label Trial.
Kadry, Z., et al. Transplantation Direct 2021; 7(7): e709.

A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial.
Zhang, Y., et al Stem Cell Research & Therapy 2021; 12(1): 244.

Heart transplantation

Allograft discard risk index for heart transplantation.
Reul, R. M., Jr., et al. Clinical Transplantation 2021 [record in progress].

Various organs

Simultaneous pancreas and kidney transplantation for end-stage kidney disease patients with type 2 diabetes mellitus: a systematic review and meta-analysis.
Cao, Y., et al. Langenbecks Archives of Surgery 2021 [record in progress].

Other

Randomized controlled trial of a quadratus lumborum block with liposomal bupivacaine for post-operative analgesia in laparoscopic donor nephrectomy.
Gritsch, H. A., et al. Clinical Transplantation 2021 [record in progress]