Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

January 2020

Kidney transplantation

Prophylaxis of Wound Infections-antibiotics in Renal Donation (POWAR): A UK Multicentre Double blind Placebo Controlled Randomised Trial.
Ahmed, Z., Uwechue, R. et al. (2019). Annals of Surgery [record in progress].

Mobile medication manager application to improve adherence with immunosuppressive therapy in renal transplant recipients: A randomized controlled trial.
Han, A., Min, S. I. et al. (2019). PLoS ONE [Electronic Resource] 14(11): e0224595.

Long-term, prolonged-release tacrolimus-based immunosuppression in de novo kidney transplant recipients: 5-year prospective follow-up of the ADHERE study patients.
Rummo, O., Carmellini, M. et al. (2019). Transplant International [record in progress].

Peritransplant eculizumab does not prevent delayed graft function in deceased donor kidney transplant recipients: Results of two randomized controlled pilot trials.
Schroppel, B., Akain, E. et al. (2019). American Journal of Transplantation [record in progress].

Impact of Navigators on First Visit to a Transplant Center, Waitlisting, and Kidney Transplantation: A Randomized, Controlled Trial.
Sullivan, C. M., Barnswell, K. V. et al. (2018). Clinical Journal of The American Society of Nephrology: CJASN 13(10): 1550-1555.

Long term graft survival and graft function following pregnancy in kidney transplant recipients: a systematic review and meta-analysis.
van Buren, M. C., Schellekens, A. et al. (2019). Transplantation; [record in progress].

Belatacept-Based Immunosuppression With Simultaneous Calcineurin Inhibitor Avoidance and Early Corticosteroid Withdrawal: A Prospective, Randomized Multicenter Trial.
Woodle, E. S., Kaufman, D. et al. (2019). American Journal of Transplantation [record in progress].

Heart transplantation

Sex-mismatch influence on survival after heart transplantation: A systematic review and meta-analysis of observational studies.
Ayesta, A., UrrĂștia, G. et al. (2019). Clinical Transplantation; 33(12): e13737.

Lung transplantation

A randomised single-centre trial of inhaled liposomal cyclosporine for bronchiolitis obliterans syndrome post-lung transplantation.
Iacono, A., Wijesinha, M. et al. (2019). Erj Open Research 5(4).

Various organs

Assessing the acceptability and efficacy of teens taking charge: Transplant-A pilot randomized control trial.
Korus, M., Cruchley, E. et al. (2019). Pediatric Transplantation [record in progress].