Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.


March 2020

Kidney transplantation

Target of rapamycin inhibitors (TOR-I; sirolimus and everolimus) for primary immunosuppression in kidney transplant recipients.
Hahn, D. et al. Cochrane Database of Systematic Reviews 2019; 12: CD004290.

Remote ischaemic conditioning and early changes in plasma creatinine as markers of one year kidney graft function-A follow-up of the CONTEXT study.
Nielsen, M. B. et al. PLoS ONE [Electronic Resource] 2019; 14(12): e0226882.

Perioperative fosfomycin disodium prophylaxis against urinary tract infection in renal transplant recipients: a randomized clinical trial.
Rosado-Canto, R. et al. Nephrology Dialysis Transplantation [record in progress].

Increasing Time in Therapeutic Range of Tacrolimus in the First Year Predicts Better Outcomes in Living-Donor Kidney Transplantation.
Song, T. et al. Frontiers in Immunology [record in progress].

Heart transplantation

Association of Clinical Outcomes With Left Ventricular Assist Device Use by Bridge to Transplant or Destination Therapy Intent: The Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With HeartMate 3 (MOMENTUM 3) Randomized Clinical Trial.
Goldstein, D. J. et al. JAMA Cardiology [record in progress].

Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients: Long-term Follow-up From the Randomized SCHEDULE Study.
Gustafsson, F. et al. Transplantation [record in progress].

Various organs

Randomised controlled trial to evaluate the influence of mHealth and eHealth skin cancer prevention education among young organ transplant recipients: the HIPPOlino intervention study.
Böttcher S, Buck C, et al. BMJ Open. 2019;9(12):e028842.

A Randomized Trial of Intravenous Thyroxine for Brain-Dead Organ Donors With Impaired Cardiac Function.
Dhar, R. et al. Progress in Transplantation [record in progress].

Increasing Organ Donor Designation Rates in Adolescents: A Cluster Randomized Trial.
Rodrigue JR, Boger M, et al. Am J Public Health. 2019 Sep;109(9):1273-1279

A randomized, controlled, behavioral intervention to promote walking after abdominal organ transplantation: results from the LIFT study.
Serper M, Barankay I, et al. Transplant International 2020 [record in progress]