Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.


June 2024

Kidney transplantation

Effect of Spironolactone on Kidney Function in Kidney Transplant Recipients: A Randomized Placebo-Controlled Clinical Trial.
Mortensen, L. A., et al. Clinical Journal of The American Society of Nephrology: CJASN 2024 [record in progress].

Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone for urinary tract infections and asymptomatic bacteriuria in de novo kidney transplant recipients: The Manotras study.
Rau, M., et al. Nefrologia (Engl Ed) 2024 [record in progress].

Efficacy and Safety of Bleselumab in Preventing the Recurrence of Primary Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Phase 2a, Randomized, Multicenter Study.
Shoji, J., et al. Transplantation 2024 [record in progress].

Why do people sell their kidneys? A thematic synthesis of qualitative evidence.
Shrestha, B., et al. PLOS Global Public Health 2024; 4(3): e0003015.

Fixed low dose versus concentration-controlled initial tacrolimus dosing with reduced target levels in the course after kidney transplantation: results from a prospective randomized controlled non-inferiority trial (Slow & Low study).
Stumpf, J., et al. EClinicalMedicine 2024; 67: 102381.

Liver transplantation

Association of Cytomegalovirus (CMV) DNAemia With Long-Term Mortality in a Randomized Trial of Preemptive Therapy and Antiviral Prophylaxis for Prevention of CMV Disease in High-Risk Donor Seropositive, Recipient Seronegative Liver Transplant Recipients.
Kumar, L., et al Clinical Infectious Diseases 2024; 78(3): 719-722.

Effect of dexmedetomidine on the incidence of postoperative acute kidney injury in living donor liver transplantation recipients: A randomized controlled trial.
Kwon, H. M., et al. International Journal of Surgery 2024 [record in progress].

Heart transplantation

Use of induction therapy post-heart transplantation: Clinical practice recommendations based on systematic review and network meta-analysis of evidence.
Foroutan, F., et al. Clinical Transplantation 2024; 38(3): e15270.

Cost-Effectiveness of Cardiovascular Magnetic Resonance for Rejection Surveillance After Cardiac Transplantation in the Australian Health Care System.
Pouliopoulos, J., et al. Heart, Lung & Circulation 2024 [record in progress].

Lung transplantation

Randomized trial of routine versus on-demand intraoperative extracorporeal membrane oxygenation in lung transplantation: A feasibility study.
Nasir, B. S., et al. Journal of Heart & Lung Transplantation 2024; 43(6): 1005-1009.