Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.


December 2018

Kidney transplantation

Gender differences in medication adherence among adolescent and young adult kidney transplant recipients.
Boucquemont J, Pai AL, et al. Transplantation, 2018; [record in progress].

Steroid withdrawal improves blood pressure control and nocturnal dipping in pediatric renal transplant recipients: analysis of a prospective, randomized, controlled trial.
Hocker B, Weber LT, et al. Pediatric Nephrology, 2018; [record in progress].

Onset and progression of diabetes in kidney transplant patients receiving everolimus or cyclosporine therapy: an analysis of two randomized, multicenter trials.
Sommerer C, Witzke O, et al. BMC Nephrology, 2018; 19(1): 237.

Liver transplantation

Evolution of dynamic, biochemical, and morphological parameters in hypothermic machine perfusion of human livers: A proof-of-concept study.
Abudhaise H, Davidson BR, et al. PLoS ONE, 2018; 13(9): e0203803.

Tacrolimus and Single Intraoperative High-dose of Anti-T-lymphocyte Globulins Versus Tacrolimus Monotherapy in Adult Liver Transplantation: One-year Results of an Investigator-driven Randomized Controlled Trial.
Iesari S, Ackenine K, et al. Annals of Surgery, 2018; 268(5): 776-783.

Prevalence and impact of de novo DSA during a multicenter immunosuppression withdrawal trial in adult liver transplant recipients.
Jucaud V, Shaked A, et al. Hepatology, 2018; [record in progress].

Video clinics versus standard face-to-face appointments for liver transplant patients in routine hospital outpatient care: study protocol for a pragmatic randomised evaluation of myVideoClinic.
O'Connell Francischetto E, Damery S, et al. Trials, 2018; 19(1): 574.

Heart transplantation

Blood Pressure in De novo Heart Transplant Recipients Treated with Everolimus Compared with a Cyclosporine-Based Regimen: Results from the Randomized SCHEDULE Trial.
Andreassen AK, Broch K, et al. Transplantation, 2018; [record in progress].

Various organs

A web-based education program to encourage organ donation registration among lower-educated adolescents in the Netherlands: study protocol for a cluster randomized controlled trial.
Steenaart E, Crutzen R, et al. Trials, 2018; 19(1): 532.

Other

A systematic review and meta-analysis of cold in situ perfusion and preservation for pancreas transplantation.
Hameed AM, Wong G, et al. Hpb, 2017; 19: 933-943.