Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

May 2022

Kidney transplantation

Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: systematic review and meta-analysis.
Chaudhry, D., et al. BMJ 2022; 376: e068769.

Kidney Autotransplantation for Renal Artery Aneurysm: Case Series and a Systematic Review.
Contarini, E., et al. Annals of Vascular Surgery 2021; 77: 349.e345-349.e318.

A Randomized Controlled Trial on Safety of Steroid Avoidance in Immunologically Low-Risk Kidney Transplant Recipients.
Ekberg, J., et al. KI Reports 2022; 7(2): 259-269.

Efficacy and Safety of Iguratimod Supplement to the Standard Immunosuppressive Regimen in Highly Mismatched Renal Transplant Recipients: A Pilot Study.
Tao, J., et al. Frontiers in Immunology 2021; 12: 738392.

Effect of allopurinol drug use on GFR and proteinuria in patients with renal transplant recipients (ADOPTR study).
Usalan, O., et al. Transplant Immunology 2022; 72: 101560.

Lung transplantation

A pilot randomized controlled trial of de novo belatacept-based immunosuppression following anti-thymocyte globulin induction in lung transplantation.
Huang, H. J., et al. American Journal of Transplantation 2022 [record in progress].

Five-Year Outcome of an Early Everolimus-based Quadruple Immunosuppression in Lung Transplant Recipients: Follow-Up of the 4EVERLUNG Study.
Kneidinger, N., et al. Transplantation 2022; 03: 08.

Feasibility and Usefulness of Self-Hypnosis in Patients Undergoing Double-Lung Transplantation During the Pre- and Postoperative Periods: A Randomized Study.
Michel-Cherqui, M., et al. Journal of Cardiothoracic & Vascular Anesthesia 2022 [record in progress].

Various organs

Chemoprevention of cutaneous squamous cell carcinoma and its precursors in solid organ transplant recipients using topical sirolimus: a randomized, double-blind, placebo-controlled pilot trial.
Chong, S., et al. Journal of the American Academy of Dermatology 2022 [record in progress].

Donor-Transmitted Cancer in Orthotopic Solid Organ Transplant Recipients: A Systematic Review.
Greenhall, G. H. B., et al. Transplant International 2021; 35: 10092.