Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

April 2021

Kidney transplantation

A Randomized Clinical Trial of Anti-IL-6 Antibody Clazakizumab in Late Antibody-Mediated Kidney Transplant Rejection.
Doberer, K., et al. Journal of the American Society of Nephrology 2020; 32(3):708-722.

Comparison of the effect of single vs dual antiplatelet agents on post-operative haemorrhage after renal transplantation: A systematic review and meta-analysis.
Lee, T., et al. Transplantation Reviews 2021; 35(1): 100594.

Use of Basiliximab with the Standard Immunosuppressive Protocol in Pediatric Renal Transplantation: A Double-Blind Randomized Clinical Trial.
Shemshadi, M., et al. International Journal of Organ Transplantation Medicine 2020; 11(1): 8-14.

Early Corticosteroid Cessation vs Long-term Corticosteroid Therapy in Kidney Transplant Recipients: Long-term Outcomes of a Randomized Clinical Trial.
Woodle, E. S., et al. JAMA Surgery 2021 [record in progress].

Liver transplantation

COVID-19 in hospitalized liver transplant recipients: an early systematic review and meta-analysis.
Jayant, K., et al Clinical Transplantation 2021 [record in progress].

Assessment of the Clinical Impact of a Liver-Specific, BCAA-Enriched Diet in Major Liver Surgery.
Krapf, J., et al. Transplantation Proceedings 2021; 53(2):624-629.

Heart transplantation

Clinical Manifestations and Outcomes of Coronavirus Disease-19 in Heart Transplant Recipients: A Multicenter Case Series with a Systematic Review and Meta-Analysis.
Granger, C., et al. Transplant International 2021 [record in progress].

Lung transplantation

Combined low-dose everolimus and low-dose tacrolimus after Alemtuzumab induction therapy: a randomized prospective trial in lung transplantation.
Benazzo, A., et al. Trials [Electronic Resource] 2021; 22(1): 6.

Various organs

Effect of Different Types of Messages on Readiness to Indicate Willingness to Register for Organ Donation During Driver's License Renewal in Japan.
Hirai, K., et al. Transplantation 2020; 104(12): 2591-2598.