Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.


December 2022

Kidney transplantation

Prolonged-Release Once-Daily Formulation of Tacrolimus Versus Standard-of-Care Tacrolimus in de novo Kidney Transplant Patients Across Europe.
Budde, K., et al. Transplant International 2022; 35: 10225.

Subjective cognitive complaints in end-stage renal disease: a systematic review and meta-analysis.
Chan, F. H. F., et al. Health Psychology Review 2022 [record in progress].

Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients.
Hricik, D., et al. Journal of the American Society of Nephrology 2022 [record in progress].

Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: A 2-year diagnostic accuracy study of participants from a randomized controlled trial.
Kurnikowski, A., et al. American Journal of Transplantation 2022 [record in progress].

Metabolic and functional effects of exercise training in diabetic kidney transplant recipients.
Michou, V., et al. World Journal of Transplantation 2022; 12(7): 184-194.

Comparison of Kidney Transplantation Outcomes Between Patients with and Without Pre-transplantation Bariatric Surgery: a Systematic Review.
Mousapour, P., et al. Obesity Surgery 2022 [record in progress].

Liver transplantation

Controlled oxygenated rewarming as novel end-ischemic therapy for cold stored liver grafts. A randomized controlled trial.
Minor, T., et al Clinical and translational science 2022 [record in progress].

Tacrolimus 4-hour monitoring in liver transplant patients is non-inferior to trough monitoring: the randomized controlled FK04 trial.
Ruijter, B. N., et al. Clinical Transplantation 2022 [record in progress].

Heart transplantation

Five-Year Outcomes in Patients With Fully Magnetically Levitated vs Axial-Flow Left Ventricular Assist Devices in the MOMENTUM 3 Randomized Trial.
Mehra, M. R., et al. JAMA 2022; 328(12): 1233-1242.