Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

May 2020

Kidney transplantation

Effects of low versus standard pressure pneumoperitoneum on renal syndecan-1 shedding and VEGF receptor-2 expression in living-donor nephrectomy: a randomized controlled study
Aditianingsih, D., et al. BMC Anesthesiology 2020; 20(1): 37.

Long-term effect of azithromycin in bronchiolitis obliterans syndrome.
Gan, C. T., et al. BMJ open respiratory research 2019; 6(1): e000465.

Cellular Immunity to Predict the Risk of Cytomegalovirus Infection in Kidney Transplantation: A Prospective, Interventional, Multicenter Clinical Trial
Jarque, M., et al. Clinical Infectious Diseases 2020 [record in progress]

Effect of Optimized Immunosuppression (Including Rituximab) on Anti-Donor Alloresponses in Patients With Chronically Rejecting Renal Allografts
Shiu, K. Y., et al. Frontiers in Immunology 2020 [record in progress]

Effects, costs and implementation of monitoring kidney transplant patients' tacrolimus levels with Dried Blood Spot sampling: a randomized controlled hybrid implementation trial
Veenhof, H., et al. British Journal of Clinical Pharmacology 2020 [record in progress]

Liver transplantation

Meta-analysis and Meta-regression of Survival After Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma.
Cambridge, W. A., et al. Annals of Surgery 2020 [record in progress]

Effects of pre-transplant L-carnitine supplementation on primary graft dysfunction in liver transplant recipients: a pilot, randomized, placebo-controlled clinical trial.
Khajeh, B., et al. Research in Pharmaceutical Sciences 2019; 14(6): 504-514.

Various organs

Comparison of a Behavioral Versus an Educational Weight Management Intervention After Renal Transplantation: A Randomized Controlled Trial.
Schmid-Mohler, G. et al Transplantation Direct 2019 Nov 15;5(12):e507

Challenges of calcineurin inhibitor withdrawal following combined pancreas and kidney transplantation: Results of a prospective, randomized clinical trial.
Stock, P. G., et al. American Journal of Transplantation 2020 [record in progress]

Residual risk of infection with blood-borne viruses in potential organ donors at increased risk of infection: systematic review and meta-analysis.
Waller, K.M., et al. Med J Aust. 2019;211(9):414-420