To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
September 2024
Kidney transplantation
Nonclinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK polyomavirus VP1.
Abend, J. R., et al. American Journal of Transplantation 2024 [record in progress].
A Randomized Trial Comparing Imlifidase to Plasmapheresis in Kidney Transplant Recipients With Antibody-Mediated Rejection.
Halleck, F., et al. Clinical Transplantation 2024; 38(7): e15383.
Randomized Controlled Trial of Enhanced Recovery After Surgery Protocols in Live Kidney Donors: ERASKT Study.
Saks, J., et al. Transplantation Direct 2024; 10(7): e1663.
Normothermic and hypothermic machine perfusion preservation versus static cold storage for deceased donor kidney transplantation.
Tingle, S. J., et al. Cochrane Database of Systematic Reviews 2024; 7: CD011671.
Liver transplantation
Defatting of donor transplant livers during normothermic perfusion-a randomised clinical trial: study protocol for the DeFat study.
Abbas, S. H., et al. Trials [Electronic Resource] 2024; 25(1): 386.
Substantial decline of organ preservation fluid contamination following adoption of ischemia-free liver transplantation: a post-hoc analysis.
International Journal of Surgery 2024; 110(5): 2855-2864. Lin, J., et al.
Routine end-ischemic hypothermic machine perfusion in liver transplantation from donors after brain death: results of two-year follow-up of a randomized controlled trial.
Morawski, M., et al. International Journal of Surgery 2024 [record in progress].
Heart transplantation
Long-term follow-up of the randomized, prospective Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance (SCHEDULE) trial.
Bollano, E., et al. Journal of Heart & Lung Transplantation 2024 [record in progress].
The association between body mass index, exercise capacity, and health-related quality of life in heart transplant recipients.
Holt, M. F., et al. Frontiers in Transplantation 2024; 3: 1379695.
Various organs
Impact of pre-existing frailty on survival outcomes in solid-organ transplant candidates and recipients: A meta-analysis.
Geng, D., et al. Ageing Research Reviews 2024; 99: 102364.