Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

November 2019

Kidney transplantation

Efficacy and safety of bleselumab in kidney transplant recipients: A phase 2, randomized, open-label, noninferiority study.
Harland, R. C., Klintmalm, G. et al. (2019). American Journal of Transplantation [record in progress].

Effectiveness of Antithymocyte Globulin Induction Dosing Regimens in Kidney Transplantation Patients: A Network Meta-analysis.
Lee, J. H., Kim, K. Y. et al. (2019). Transplantation Proceedings [record in progress].

A 3-month, multicenter, randomized, open-label study to evaluate the impact on wound healing of the early [vs. delayed] introduction of everolimus in de novo kidney transplant recipients, with a follow-up evaluation at 12 month after transplant (NEVERWOUND study).
Manzia, T. M., Carmellini, M. et al. (2019). Transplantation [record in progress].

Impact of Once- Versus Twice-Daily Tacrolimus Dosing on Medication Adherence in Stable Renal Transplant Recipients: A Canadian Single-Center Randomized Controlled Trial.
Paterson, T. S. E., Demian, M. et al. (2019). Canadian Journal of Kidney Health & Disease [record in progress].

Machine learning in predicting graft failure following kidney transplantation: A systematic review of published predictive models.
Senanayake, S., White, N. et al. (2019). International Journal of Medical Informatics [record in progress].

Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review.
Shah, S., Venkatesan, R. L. et al. (2019). BMC Nephrology [record in progress].

Early remote ischaemic preconditioning leads to sustained improvement in allograft function after live donor kidney transplantation: long-term outcomes in the REnal Protection Against Ischaemia-Reperfusion in transplantation (REPAIR) randomised trial.
Veighey, K. V., Nicholas, J. M. et al. (2019). Br J Anaesth [record in progress].

Liver transplantation

Alcohol relapse and its predictors after liver transplantation for alcoholic liver disease: a systematic review and meta-analysis.
Chuncharunee, L., Yamashiki, N. et al. (2019). BMC Gastroenterology [record in progress].

Telemedicine Based Remote Home Monitoring After Liver Transplantation: Results of a Randomized Prospective Trial.
Lee, T. C., Kaiser, T. E. et al. (2019). Annals of Surgery [record in progress].

Effect of sevoflurane and propofol on acute kidney injury in pediatric living donor liver transplantation.
Li, H., Weng, Y. et al. (2019). Annals of Translational Medicine 7(14): 340.