Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

February 2024

Kidney transplantation

Comparative Study of Intravenous Immunoglobulin and Leflunomide Combination Therapy With Intravenous Immunoglobulin Single Therapy in Kidney Transplant Patients With BK Virus Infection: Single-Center Clinical Trial.
Experimental & Clinical Transplantation: Official Journal of Rasaei, N., et al.

Graft retrieval incisions in minimally invasive donor nephrectomy: Systematic review and network meta-analysis.
Fong, K. Y., et al. Transplantation Reviews 2024; 38(1): 100813.

Prevalence and risk factors of urinary tract infection in kidney recipients: a meta-analysis study.
Hosseinpour, M., et al. BMC Nephrology 2023; 24(1): 284.

A randomized trial of continuous glucose monitoring to improve post-transplant glycemic control.
Jandovitz, N., et al. Clinical Transplantation 2023 [record in progress].

Sexual Function in Renal Transplant Recipients with Internal versus External Iliac Artery Anastomosis: A Randomized Clinical Trial.
Javid, A., et al. Urology Journal 2023 [record in progress].

Preventing kidney transplant failure by screening for antibodies against human leucocyte antigens followed by optimised immunosuppression: OuTSMART RCT.
Stringer, D., et al. Efficacy and Mechanism Evaluation 2023;10(5).

Liver transplantation

Factors associated with mechanical ventilation longer than 24 h after liver transplantation in patients at risk for bleeding.
Caballero, M., et al. BMC Anesthesiology 2023; 23(1): 356.

Does liraglutide alleviates inflammation in brain-dead donors? A randomized clinical trial.
Custodio, G., et al. Liver Transplantation 2023 [record in progress].

Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation (PILOTTM): A randomized, open-label, clinical trial.
Panayotova, G. G., et al. Hepatology 2023 [record in progress].

Heart transplantation

Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors.
Dhar, R., et al. New England Journal of Medicine 2023; 389(22): 2029-2038.