Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.


August 2019

Kidney transplantation

Transplantation and diabetes (Transdiab): a pilot randomised controlled trial of metformin in impaired glucose tolerance after kidney transplantation
Alnasrallah, B., Goh, T. L. et al. (2019). BMC Nephrology; 20(1): 147.

Two-year outcomes in de novo renal transplant recipients receiving everolimus-facilitated calcineurin inhibitor reduction regimen from TRANSFORM study.
Berger, S. P., Sommerer, C. et al. (2019). American Journal of Transplantation; [record in progress].

GCV/VCVG prophylaxis against CMV DNAemia in pediatric renal transplant patients: A systematic review and meta-analysis.
Chatani, B., Glaberson, W. et al. (2019). Pediatric Transplantation; [record in progress].

Multicentre randomised controlled trial protocol of urine CXCL10 monitoring strategy in kidney transplant recipients.
Ho, J., Sharma, A. et al. (2019). BMJ Open; 9(4): e024908.

A randomized, open-label pharmacokinetic trial of tacrolimus extended-release dosing in obese de novo kidney transplant recipients.
Jasiak-Panek, N. M., Wenzler, E. et al. (2019). Clinical Transplantation; [record in progress].

Immunogenicity and Safety of the Adjuvanted Recombinant Zoster Vaccine in Chronically Immunosuppressed Adults Following Renal Transplant: a Phase III, Randomized Clinical Trial.
Vink, P., et al. Ramon Torrell, J. M. (2019). Clinical Infectious Diseases; 07: 07.

A randomized controlled trial of Explore Transplant at Home to improve transplant knowledge and decision-making for CKD 3-5 patients at Kaiser Permanente Southern California.
Waterman, A. D., Anderson, C. et al. (2019). BMC Nephrology; 20(1): 78.

Liver transplantation

The hepatic protective effects of tacrolimus as a rinse solution in liver transplantation: A meta-analysis.
Guo, T., Lei, J. et al. (2019). Medicine (Baltimore); 98(21): e15809.

Pharmacokinetic Profile of Prolonged-Release Tacrolimus When Administered via Nasogastric Tube in De Novo Liver Transplantation: A Sub-Study of the DIAMOND Trial.
Undre, N., Baccarani, U. et al. (2019). Annals of Transplantation; 14(24): 268-272.

Lung transplantation

Transplant suitability of rejected human donor lungs with prolonged cold ischemia time in low flow acellular and high flow cellular ex vivo lung perfusion systems.
Okamoto, T., Wheeler, D. et al. (2019). Transplantation; 12: 12.