Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

July 2021

Kidney transplantation

Preformed T-cell alloimmunity and HLA eplet mismatch to guide immunosuppression minimization with Tacrolimus monotherapy in Kidney Transplantation. Results of the CELLIMIN trial.
Bestard, O., et al. American Journal of Transplantation 2021 [record in progress].

Impact of a pharmacist-led, mHealth-based intervention on tacrolimus trough variability in kidney transplant recipients: A report from the TRANSAFE Rx randomized controlled trial.
Fleming, J. N., et al. American Journal of Health System Pharmacy 2021 [record in progress].

Economic Consequences of Adult Living Kidney Donation: A Systematic Review.
Fu, R., et al. Value in Health 2021; 24(4): 592-601.

Oxygenated End-Hypothermic Machine Perfusion in Expanded Criteria Donor Kidney Transplant: A Randomized Clinical Trial.
Husen, P., et al. JAMA Surgery 2021 [record in progress].

Diagnostic accuracy of myocardial perfusion imaging in patients evaluated for kidney transplantation: A systematic review and meta-analysis.
Kelderman, J. R., et al. Journal of Nuclear Cardiology 201 [record in progress].

Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients (CANDLE-KIT): a Multicenter, 2x2 Factorial, Open-label, Randomized Clinical Trial.
Obi, Y., et al. Transplant International 2021 [record in progress].

Liver transplantation

Cost analysis of a long-term randomized controlled study in biliary duct-to-duct anastomotic stricture after liver transplantation.
Cantu, P., et al. (2021). Transplant International [record in progress].

Bisphosphonate Therapy after Liver Transplant Improves Bone Mineral Density and Reduces Fracture Rates: An Updated Systematic-Review and Meta-Analysis.
Ho, O. T. W., et al. (2021). Transplant International [record in progress].

Machine Learning for the Prediction of Red Blood Cell Transfusion in Patients During or After Liver Transplantation Surgery.
Liu, L. P., et al. (2021). Frontiers in Medicine 8: 632210.

Heart transplantation

Everolimus for the Prevention of Calcineurin-Inhibitor-Induced Left Ventricular Hypertrophy After Heart Transplantation (RADTAC Study).
Anthony, C., et al. (2021). JACC Heart Failure 9(4): 301-313.