Pregnancy Outcomes in 53 Female Lung Transplant Recipients.
Lee, F. G., et al.Chest. 2025 Oct;168(4):932-942.
Aims
This study aimed to explore modifiable risk factors associated with pregnancy outcomes in female lung transplant recipients.
Interventions
A retrospective observational cohort study was conducted using data from the Transplant Pregnancy Registry International (TPRI) database.
Participants
53 adult (≥ 18 years) female lung transplant recipient with either a history of pregnancy following lung transplantation or who were pregnant at time of enrollment.
Outcomes
The main outcomes of interest included time between transplantation and pregnancy, effects of pregnancy planning, factors associated with recipient survival, and foetal mycophenolic acid (MPA) exposure.
Follow-up
Follow-up interviews are performed by TPRI staff every 2 years.
CET Conclusions
This study examines how modifiable risk factors influence pregnancy outcomes in female lung transplant recipients. Fifty-three female lung transplant recipients reporting a total of 72 pregnancies were identified using the TPRI database. The study design being a retrospective observational cohort introduces the possibility of selection bias. The study revealed that female lung transplant recipients who planned their pregnancies showed significantly higher birth weight and longer gestational age (GA) as well as lower recipient mortality compared to lung transplant recipients with unplanned pregnancies, making the unplanned pregnancy the most modifiable risk factor. However, it is possible that confounders may have influenced the results of this analysis as they were not adjusted for. Although one of the conclusions the authors arrive at is that pregnancy following lung transplantation poses risks to both mother and the offspring, no data comparing risks between pregnant lung transplant recipients and pregnancy outcomes in the general population is presented in this paper.
Trial registration
N/A