Quality of Measurement Properties in Patient Reported Outcomes Used in Adult Liver Transplant Candidates and Recipients: a Systematic Review.
van Knippenberg, S. E. M., et al.Transpl Int. 2025 Oct 2;38:14497.
Aims
The aim of this review was to provide an overview of studies evaluating the quality of available Patient Reported Outcome Measures (PROMs) and their measurement properties in adult pateint awaiting or undergoing liver transplantation.
Interventions
MEDLINE, EMBASE, PubMed, and COCHRANE dabatases were searched for relevant literature. Studies were selected by four independent reviewers. The COSMIN Risk of Bias checklist was used to assess the quality of the incuded studies.
Participants
23 studies were included in the review.
Outcomes
Quality of measurement properties of PROMs.
Follow-up
N/A
CET Conclusions
This systematic review identifies studies describing patient-reported outcome measures (PROMS) for patients waiting for, or after, adult liver transplantation. The authors identified 23 studies describing 35 PROMS – nine of these were disease specific, and 26 were generic. The majority of studies reported low-quality evidence for measurement properties, with the post-liver transplant quality of life (pLTQ) tool demonstrating the best internal consistency, reliability and responsiveness for disease-specific reporting. The review is well designed and reported, with prospective registration of the protocol, comprehensive search strategies and quality assessment using the COSMIN checklist. It is clear from the review that some improvement is needed in this area, and future studies should investigate the validity of the commonly used PROMS for different indications and populations.
Trial registration
PROSPERO - CRD42021251533