Feasibility, Acceptability, and Satisfaction of a Lifestyle Intervention for Post-Transplant Weight Loss.
Cote, M. P., et al.Transplant Proc. 2025 Dec;57(10):1999-2009.
Aims
The main aim of the study was to evaluate the feasibility and acceptability of a multicomponent lifestyle intervention for weight loss in posttransplant patients
Interventions
Participants were randomly assigned to two groups. Patients in the control group received connected health devices (Fitbit and body-weight scale) and nutritional coaching phone calls every 2 months. The intervention group received the same devices and coaching calls plus virtual educational group sessions on lifestyle modification every other month. Control group participants who were unable to lose ≥2.5% of their body weight received an invitation to crossover to the intervention arm at 6 months.
Participants
24 posttransplant patients (12 kidney transplant and 12 liver transplant recipients)
Outcomes
The primary endpoint was feasibility and acceptability using the Acceptability of Intervention Measure (AIM), Intervention Appropriateness Measure (IAM) and Feasibility of Intervention Mea-sure (FIM) surveys. The secondary endpoint was the percentage of total body weight loss.
Follow-up
12 months
CET Conclusions
The lifestyle intervention rolled out in this study consisted of nutritional coaching for 12 months, provision of a “fit bit” and weighing scale. The study was small, including only 12 patients in each study arm. Despite being small in number, there is still missing data from 6- and 12-month study visits. Four patients did not provide an exit interview. The study was a feasibility focus and hence did not monitor weight loss as an outcome. The results for acceptability, appropriateness and feasibility were moderate. Fit-bit usage was good; however, scale usage was not as popular and dropped off. The crossover of some patients at 6-months follow up, and the fact that some patients chose not to cross-over to the intervention group could impact the conclusions.
Data analysis
Strict intention-to-treat analysis
Trial registration
ClinicalTrials.gov - NCT06249477