Transplant Trial Watch

Liver Transplantation for Wilson's Disease in Non-adult Patients: A Systematic Review.

Garoufalia, Z., Prodromidou, A. et al. (2019).

Transplantation Proceedings 51(2): 443-445.


Aims
This study reviews the outcomes of paediatric Wilson Disease (WD) patients after liver transplantation and to study the role of liver transplantation in WD patients.

Interventions
PubMed was searched for all articles published from inception-October 2017 on presenting cases of paediatric liver transplant patients as a result of Wilson’s Disease.

Participants
Six articles with a total of 290 paediatric patients were included in this systematic review.

Outcomes
Outcomes were assessed as chronic liver failure, fulminant liver failure, average 1-year and 5-year survival rate and retransplantation.

Follow-up
5 years.

CET Conclusions
This short paper reports a systematic review of liver transplantation in paediatric patients with Wilson’s Disease. Only pubmed was searched, neglecting other potential sources of papers and studies were excluded for quite a variety of reasons. It is not clear if the searches and paper selection was done in duplicate or by one author alone. The included papers were retrospective case series, which can make quality assessment less straightforward, however the authors have not presented any quality indicators for their included studies or assessed for risk of bias. There is also no in-depth discussion of differences between the included series. The paper therefore does not add much more to the literature on this topic beyond the case series already published. In the included series the 5-year graft survival ranged from 83.9-96.6%.

Trial registration
N/A

Funding source
Not reported