Particle Flow Profiles From the Airways Measured by PExA Differ in Lung Transplant Recipients Who Develop Primary Graft Dysfunction.Broberg, E., Hyllén, S. et al. (2019).
Experimental & Clinical Transplantation; [record in progress].
This study aimed to identify whether patients who developed primary graft dysfunction following lung transplantation had different particle flow patterns from the airways, using PExA.
Patients were randomized to either daily volumecontrolled ventilation or pressure-controlled ventilation as the first mode of treatment until extubation.
12 lung transplant recipients.
The primary outcome that was assessed was primary graft dysfunction and particle count from day 0 until extubation.
This small single-centre study assesses the safety of using a customized PExA particle flow monitor in ventilated patients post-transplant. Patients were randomized to either volume-controlled or pressure-controlled ventilation: the aim of randomization was to see if the particle flow rates differed in different ventilation modes rather than randomizing the intervention itself. The authors demonstrate that patients with primary graft dysfunction show a gradual increase in particle counts over the first few days post-transplant, which can be used to detect transplant dysfunction prior to clinical manifestation. The study is small, but this may prove a promising tool for the early detection of PGD.