Transplant Trial Watch

Clinical Manifestations and Outcomes of Coronavirus Disease-19 in Heart Transplant Recipients: A Multicenter Case Series with a Systematic Review and Meta-Analysis.

Granger, C., et al.

Transplant International 2021 [record in progress].

This study aimed to investigate the impact of coronavirus disease-19 (COVID-19) in heart transplant (HT) recipients.

Databases such as Pubmed and Embase were searched. Data extraction was performed by two investigators.

4 studies were included in the review.

The main outcome of interest was the incidence of death (from any cause).


CET Conclusions
The authors report a case series from three French transplant centres (n=39) and a systematic review reporting the mortality following COVID-19 infection in heart transplant recipients. A bibliographic search of PubMed and Embase identified 41 eligible observational studies, including case reports. Studies reporting on at least 10 patients were included in pooled analyses to explore potential risk factors of death. Data were extracted by two independent reviewers. The pooled proportion of death (including the French case series) was 22.1% (n=398, 95% confidence interval 18.3–26.4%). Meta-analyses of four studies showed that pre-existing diabetes mellitus and chronic kidney disease stage III or higher were associated with death although the confidence intervals were wide due to the small sample size. Age as a potential risk factor was not investigated.

Trial registration

Funding source
No funding received