Transplant Trial Watch

Cardiac surgery outcomes in patients with antecedent kidney, liver, and pancreas transplantation: a meta-analysis.

Bacusca, A. E., et al.

Reviews in Cardiovascular Medicine 2020; 21(4): 589-599.

This study aimed to compare cardiac surgery outcomes in abdominal solid organ transplant patients versus nontransplant (N-Tx) patients.

Electronic databases including Pubmed, SCOPUS and EMBASE were searched. Study screening and data extraction were perfomed by two reviewers. The Newcastle-Ottawa Quality Assessment Scale for cohort studies was used to assess the risk of bias.

5 studies were included in the review.

The main endpoints included overall infectious complication rate, cardiovascular and renal events, and mortality following cardiac surgery in patients with prior solid organ transplantation versus nontransplant patients.


CET Conclusions
The systematic review compared postoperative outcomes of cardiac surgery in abdominal solid organ transplant recipients versus nontransplant patients. A comprehensive search of three bibliographic databases was conducted and two independent reviewers identified five comparative studies to include in kidney, liver, pancreas and pancreas-kidney transplantation. Two independent reviewers extracted the data and methodological quality was also assessed although it was not stated whether this was done by independent reviewers. All studies were considered to be of good methodological quality. Transplant recipients experienced worse postoperative outcomes, i.e. higher rates of wound infection, septicaemia, cardiac tamponate, kidney failure, and 5-year and 10-year mortality. No differences were found for pneumonia, post-procedural stroke rate and 30-day mortality. Heterogeneity was low for most analyses.

Trial registration

Funding source
Not reported