Transplant Trial Watch

Outcomes of live renal donors with a history of nephrolithiasis; A systematic review.

Bin Mohamed Ebrahim, M. E., et al.

Transplantation Reviews 2022; 37(1): 100746.

This study aimed to investigate the outcomes of kidney donors with a prior history of nephrolithiasis following donation.

A literature search was conducted on Ovid and Embase. Eligible studies were selected by two independent reviewers. The Newcastle-Ottawa scale was used to assess the quality of the included studies.

14 studies were included the review.

The primary outcome was stone-related event including stone-formation following donation, stone-induced obstruction, acute renal failure and sepsis. The secondary outcomes included short-term (≤30 days) and long-term (≥12 months) renal function.


CET Conclusions
This systematic review explores the published data regarding living kidney donors with a history of renal stones. The authors identified 14 studies of 432 patients, identifying just one patient with a reported stone-related event. However, the identified studies were limited in quality and detail, and the average follow-up was just 21.1 months. Review methodology is good, with protocol registration, thorough literature search strategies and quality assessment. The authors make the best of the literature available with a comprehensive and well-written summary, but as they point out, there is significant risk of publication bias and under-reporting. More robust long-term registry data is required to truly quantify the risk to donors with existing stone disease.

Trial registration
PROSPERO - CRD42021271244

Funding source
Not reported