Transplant Trial Watch

A Systematic Review and Meta-Analysis of Posttransplant Anemia With Overall Mortality and Cardiovascular Outcomes Among Kidney Transplant Recipients.

Mekraksakit, P., et al.

Progress in Transplantation 2023 [record in progress].

This study aimed to investigate the outcomes associated with posttransplant anaemia (PTA) in kidney transplant recipients.

Electronic databases including MEDLINE and EMBASE were searched. Study selection and data extraction were performed by two independent reviewers. The methodological quality of the included studies was assessed using the Newcastle-Ottawa scale.

17 studies were included in the review.

The primary outcomes were cardiovascular death and major adverse cardiovascular events (MACE). The secondary outcomes included overall mortality and graft loss.


CET Conclusions
This systematic review aimed to assess the impact of posttransplant anaemia (PTA) on overall mortality, graft loss and cardiovascular outcomes. Two electronic databases were used to conduct the literature search. Study screening and data extraction were performed in duplicate. A total of 17 studies were included, all of which were observational cohort studies. The authors concluded that kidney transplant recipients (KTRs) with PTA had a significantly higher risk of overall mortality, graft loss, cardiovascular death and major adverse cardiovascular events (MACE), in comparison to KTRs without PTA. Heterogeneity was significant for some of the outcomes, which the authors speculated were due to differences in demographics, study design, and in definitions and onsets of PTA in each study. No attempts were made to adjust for the effect of confounders in the analysis.

Trial registration
PROSPERO - CRD42021256762

Funding source
No funding received