Kidney Transplantation From Donors With Acute Kidney Injury: Are the Concerns Justified? A Systematic Review and Meta-Analysis.
Nita, G. E., et al.Transplant International 2023; 36: 11232.
Aims
The aim of this study was to investigate the posttransplant outcomes of transplanting kidneys from donors with acute kidney injury (AKI).
Interventions
Pubmed, Embase and the Cochrane Library databases were searched for relevant literature. Full-text were screened by two independent reviewers. The methodological quality of the included studies was assessed using the the Newcastle-Ottawa Scale (NOS) and the Oxford Centre for Evidence-Based Medicine (OCEBM) hierarchy.
Participants
30 studies were included in the review.
Outcomes
The primary outcomes were delayed graft function and primary non-function (PNF). The secondary outcomes were acute rejection, graft survival, estimated glomerular filtration rate (eGFR) and length of hospital stay (LOS).
Follow-up
N/A
CET Conclusions
The aim of this study was to investigate posttransplant outcomes associated with transplanting kidneys retrieved from donors with AKI. A total of 30 studies were included in the review, all of which were cohort studies. While full-text screening of studies for inclusion were performed by two independent reviewers, it is not mentioned whether extraction of data was also conducted in duplicate. The authors concluded that although the risk of DGF was significantly higher in the donor AKI versus the non-AKI kidney group, transplanting kidneys from donors with AKI was not found to impact long-term graft function and survival. Heterogeneity was significant for most of the outcomes but was not explored. The effect of confounders were not accounted for in the analyses.
Trial registration
N/A