To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
February 2013
Kidney transplantation
High incidence of rejection episodes and poor tolerance of sirolimus in a protocol with early steroid withdrawal and calcineurin inhibitor-free maintenance therapy in renal transplantation: experiences of a randomized prospective single-center study.
Burkhalter F, Oettl T, et al. Transplantation Proceedings 2012; 44(10):2961-2965.
Conversion to sirolimus in kidney transplant recipients with squamous cell cancer and changes in immune phenotype.
Carroll RP, Hester J, et al. Nephrology Dialysis Transplantation. 2013; 28 (2): 462-465.
Is early removal of prophylactic ureteric stents beneficial in live donor renal transplantation?
Indu KN, Lakshminarayana G, et al. Indian Journal of Nephrology 2012; 22(4):275-279.
Improved adherence to tacrolimus once-daily formulation in renal recipients: a randomized controlled trial using electronic monitoring.
Kuypers DR, Peeters PC, et al. Transplantation 2013; 95(2):333-340.
Effect of corticosteroid withdrawal on tacrolimus and mycophenolate mofetil exposure in a randomized multicenter study.
Shihab FS, Lee ST, et al. American Journal of Transplantation. 2013; 13(2): 474-484
The effect of everolimus versus mycophenolate upon proteinuria following kidney transplant and relationship to graft outcomes.
Wiseman AC, McCague K, et al. American Journal of Transplantation. 2013; 13(2):442-449
Liver transplantation
Role of liposomal amphotericin B prophylaxis after liver transplantation compared with fluconazole for high-risk patients. Impact on infections and mortality within one year.
Perrella A, Esposito C, et al. Transplantation Proceedings 2012; 44(7):1977-1981.
Liver-protecting effects of omega-3 fish oil lipid emulsion in liver transplantation.
Zhu X, Wu Y, et al. World Journal of Gastroenterology 2012; 18(42):6141-6147.
Heart transplantation
Impact of the early reduction of cyclosporine on renal function in heart transplant patients: a French randomised controlled trial.
Boissonnat P, Gaillard S, et al. Trials 2012; 13(1):231
Lung transplantation
Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors.
Ware LB, Neyrinck A, et al. Clinical Transplantation 2012; 26(5):665-671.