Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

February 2018

Kidney transplantation

Predictive Score Model for Delayed Graft Function Based on Easily Available Variables before Kidney Donation after Cardiac Death.
Ding CG, Tai QH, et al. Chinese Medical Journal 2017; 130(20): 2429-2434.

A Randomized Trial of Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection.
Eskandary F, Regele H, et al. Journal of the American Society of Nephrology 2017; 14: 14.

Efficacy and Safety Outcomes of Extended Criteria Donor Kidneys by Subtype: Subgroup Analysis of BENEFIT-EXT at 7 Years After Transplant.
Florman S, Becker T, et al. American Journal of Transplantation 2017; 17(1): 180-190.

Campath, calcineurin inhibitor reduction and chronic allograft nephropathy (the 3C Study) - results of a randomized controlled clinical trial.
Haynes R, Blackwell L, et al. American Journal of Transplantation 2017; 11: 11.

Down-regulation of inflammatory signaling pathways despite up-regulation of Toll-like receptors; the effects of corticosteroid therapy in brain-dead kidney donors, a double-blind, randomized, controlled trial.
Jafari R, Aflatoonian R, et al. Molecular immunology 2017; 94: 36-44.

Modern lymphatic dissection techniques for preventing post renal transplant lymphocele.
Lucan CV, Jurchis I, et al. Clujul Medical 2017; 90(4): 416-419.

Effectiveness of heated sterile water versus ResoClear for prevention of laparoscopic lens fogging in a randomized comparative trial.
Merkx R, Muselaers C, et al. Journal of Endourology 2017; 29: 29.

Liver transplantation

Efficacy and safety of everolimus with reduced tacrolimus in living-donor liver transplant recipients: 12-month results of a randomized multicenter study.
Jeng L, Lee SG, et al. American Journal of Transplantation 2017; 13: 13.

The new liver allocation score for transplantation is validated and improved transplant survival benefit in Germany but not in the United Kingdom.
Schrem H, Focken M, et al. Liver Transplantation 2016; 22(6): 743-756.

Various organs

Cancer evaluation in the assessment of solid organ transplant candidates: A systematic review of clinical practice guidelines.
Acuna SA, Lam W, et al. Transplantation Reviews 2017; 08: 08.