Transplant Trial Watch

To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.

The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].

The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.

Click on each trial for more detail of findings and quality.

May 2018

Kidney transplantation

Conversion from tacrolimus to everolimus with complete and early glucocorticoid withdrawal after kidney transplantation: a randomised trial.
Bouamar R, Shuker N, et al. Netherlands Journal of Medicine 2018; 76(1): 14-26.

Impact of renal allograft nephrectomy on graft and patient survival following retransplantation: a systematic review and meta-analysis.
Lin J, Wang R, et al. Nephrology Dialysis Transplantation 2018 [record in progress]

A Randomized, Placebo-Controlled Phase I Trial of Live, Attenuated Herpes Zoster Vaccine in Subjects with End Stage Renal Disease Immunized Prior to Renal Transplantation.
Miller G, Schaefer H, et al. Transplant Infectious Disease 2018; 20(3): e12874.

Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis.
O'Keeffe LM, Ramond A, et al. Annals of Internal Medicine 2018; 168(4): 276-284.

Effect of the iChoose Kidney Decision Aid in Improving Knowledge about Treatment Options among Transplant Candidates: a Randomized Controlled Trial.
Patzer RE, McPherson L, et al. American Journal of Transplantation 2018; 18(8): 1954-1965.

A randomized controlled trial-based algorithm for insulin-pump therapy in hyperglycemic patients early after kidney transplantation.
PLoS ONE [Electronic Resource] 2018; 13(3): e0193569. Werzowa JM, Saemann MD, et al.

Estimating Glomerular Filtration Rate in Kidney Transplant Recipients: Comparing a Novel Equation With Commonly Used Equations in this Population.
Salvador CL, Hartmann A, et al. Transplantation Direct 2017; 3(12): e332.

Effects of intraoperative and early postoperative normal saline or Plasma-Lyte 148 on hyperkalaemia in deceased donor renal transplantation: a double-blind randomized trial.
Weinberg L, Harris L, et al. British Journal of Anaesthesia 2017; 119(4): 606-615.

Volume Reduction in Enlarged Kidneys in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Prior to Renal Transplant with Transcatheter Arterial Embolization (TAE): A Systematic Review and Meta-Analysis.
Ye W, Voss MD, et al. Cardiovascular & Interventional Radiology 2018; 41(6): 828-834.

Liver transplantation

Renal Function Improvement by Telbivudine in Liver Transplant Recipients with Chronic Kidney Disease.
Lee W, Wu T, et al. BioMed Research International 2017:9324310.