Immortal time bias in survival analysis

By: Simon Knight | Posted on 17th December 2018

Whilst reviewing an article submitted to a transplant journal recently, my attention was brought to an issue that is often overlooked in survival analysis, called ‘immortal time bias’. The issue arises when the groups to be compared in the analysis are defined by a time-dependent event that can occur any time during follow-up. As standard […]

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The CET is hiring!

By: Simon Knight | Posted on 20th November 2018

We are looking for a Research Associate to work at the Peter Morris Centre for Evidence in Transplantation, based at the John Radcliffe Hospital. You will be working closely with the co-directors of the Centre and will be responsible for keeping the online Transplant Library up to date and accurate, and composing the Transplant Trial […]

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May 2018 Transplant Trial Watch now available

By: Simon Knight | Posted on 2nd May 2018

The May 2018 edition of the Transplant Trial Watch is now available online. This month’s studies include the impact of allograft nephrectomy on subsequent transplants, the mid- and long-term risks of living kidney donation, and the use of transcatheter arterial embolisation in patients with APKD prior to transplant.

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COPE Normothermic Liver Preservation trial published in Nature

By: Simon Knight | Posted on 19th April 2018

The first of the Consortium for Organ Preservation in Europe (COPE) organ preservation trials has now been published in Nature. The large, European, multicentre trial randomised livers to standard static cold storage, or to normothermic machine preservation using the OrganOx Metra device. The study demonstrated improved early biochemical function, with a reduction in peak ALT […]

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April 2018 Transplant Trial Watch now available

By: Simon Knight | Posted on 4th April 2018

The April 2018 Transplant Trial Watch is now available. This month’s studies include a trial of Eculizumab for prevention of ischaemia-reperfusion injury, a systematic review of liver transplantation for alcoholic hepatitis, and a review of the impact of positive preservation fluid cultures.

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March 2018 Transplant Trial Watch now available

By: Simon Knight | Posted on 2nd March 2018

The March 2018 Transplant Trial watch is now available online and via the CET app. This month’s papers include an evaluation of inclusion/exclusion criteria in transplant clinical trials, self-monitoring of kidney function after transplantation and extended versus modified right lobe grafts for live donor liver transplantation.

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February 2018 Transplant Trial Watch Now available

By: Simon Knight | Posted on 5th February 2018

The February 2018 Transplant Trial Watch is now available. This month’s articles include the results of the Borteject trial, results of the UK 3C study and a review of guidelines for cancer evaluation in solid organ transplant recipients.

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Survey on clinical trial data sharing practices in transplantation

By: Simon Knight | Posted on 29th January 2018

We are conducting an interesting study to investigate attitudes and current practices regarding anonymised clinical trial data sharing among transplant professionals. This study will provide insight regarding the facilitators and barriers of sharing data and help develop better tools and processes for data sharing in the future. Participation in the survey will only take 5 […]

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ACADEMIA – a new course from ESOT, Vienna May 2018

By: Simon Knight | Posted on 9th January 2018

The European Society in Organ Transplantation and the Centre for Evidence in Transplantation have teamed up to create a new course for future leaders in transplantation.  Replacing the Evidence in Transplantation (EVIT) course and European Transplant Fellows Workshop (ETFW), this new course aims to teach: Academic skills – research, critical appraisal, evidence based medicine, systematic […]

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Do clinical trials reflect reality?

By: Simon Knight | Posted on 9th January 2018

Renal transplant recipients and donors are becoming increasingly more marginal, with more expanded criteria (ECD) and donation after circulatory death (DCD) donors and increasingly older recipients with multiple comorbidities. Despite this, high-risk donors and recipients are often excluded from clinical trials, leading to uncertainty about the generalizability of findings. In order to highlight the extent of this […]

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