To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
October 2012
Kidney transplantation
Sirolimus and Secondary Skin-cancer Prevention in Kidney Transplantation.
Euvrard S, Morelon E, et al. New England Journal of Medicine, 367(4): 329-339, 2012.
Machine Perfusion versus Cold Storage for the Preservation of Kidneys from Donors >=65 Years Allocated in the Eurotransplant Senior Programme.
Gallinat A, Moers C, et al. Nephrology Dialysis Transplantation [record in progress].
Improvement in Renal Function in Kidney Transplant Recipients Switched from Cyclosporine or Tacrolimus to Belatacept: 2-year Results from the Long-term Extension of a Phase II Study.
Grinyo J, Alberu J, et al. Transplant International, 25(10): 1059-1064, 2012.
Tacrolimus-Based, Steroid-Free Regimens in Renal Transplantation: 3-Year Follow-up of the ATLAS Trial.
Kramer BK, Klinger M, et al. Transplantation, 94(5):492-498, 2012.
Improved Renal Function After Early Conversion From a Calcineurin Inhibitor to Everolimus: a Randomized Trial in Kidney Transplantation.
Mjornstedt L, Sorensen SS, et al. American Journal of Transplantation [record in progress].
A Multicenter, Randomized, Double-blind Study Comparing Different FK778 Doses (Manitimus) with Tacrolimus and Steroids vs. MMF with Tacrolimus and Steroids in Renal Transplantation.
Wlodarczyk Z, Vanrenterghem Y, et al. BMC Nephrology, 13(1): 68, 2012.
Liver transplantation
Use of N-acetylcysteine During Liver Procurement: A Prospective Randomized Controlled Study.
D'Amico F, Vitale A, et al. Liver Transplantation [record in progress].
Everolimus With Reduced Tacrolimus Improves Renal Function in De Novo Liver Transplant Recipients: A Randomized Controlled Trial.
De Simone P, Nevens F, et al. American Journal of Transplantation [record in progress].
A Randomized Controlled Trial of Pretransplant Antiviral Therapy to Prevent Recurrence of Hepatitis C After Liver Transplantation.
Everson GT, Terrault NA, et al. Hepatology [record in progress].
Heart transplantation
High-Intensity Interval Training Improves Peak Oxygen Uptake and Muscular Exercise Capacity in Heart Transplant Recipients.
Nytroen K, Rustad LA, et al. American Journal of Transplantation [record in progress].