To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
March 2015
Kidney transplantation
Five-Year Outcomes in Kidney Transplant Patients Converted From Cyclosporine to Everolimus: The Randomized ZEUS Study
Budde K, Lehner F, et al American Journal of Transplantation 2015; 15: 119–128
Immunophenotyping of peripheral immunoregulatory as well as Th17A and Th22 cell subpopulations in kidney transplant recipients under belatacept or cyclosporine treatment
Furuzawa-Carballeda J, Bostock IC, et al Transplant Immunology 2014;30:107–113
Induction therapy: clinical and quality of life outcomes in aged renal transplant recipients
Palanisamy AP, Al Manasra AR, et al Palanisamy AP, Al Manasra AR, et al
Kidney Transplant Recipients Carrying the CYP3A4_22 Allelic Variant Have Reduced Tacrolimus Clearance and Often Reach Supratherapeutic Tacrolimus Concentrations
Pallet N, Jannot A-S, et al American Journal of Transplantation 2015;15(3):800-5
A Phase I/II Placebo-Controlled Trial of C1-Inhibitor for Prevention of Antibody-Mediated
Vo AA, Zeevi A, et al. Transplantation 2015 99(2): 299-308
Corticosteroid-Free Kidney Transplantation Improves Growth: 2-Year Follow-up of the TWIST Randomized Controlled Trial
Webb NJ, Douglas SE, Rajai A, et al. Transplantation. 2015 Jun; 99(6): 1178-85
ATG induction in renal transplant recipients: Long-term hazard of severe infection is associated with long-term functional T cell impairment but not the ATG-induced CD4 cell decline
Weimer R, Ettrich M, et al Human Immunology 2014; 75 (6 ): 561–569
Liver transplantation
Randomized Trial of Micafungin for the Prevention of Invasive Fungal Infection in High-Risk Liver Transplant Recipients
Saliba F, Pascher A, Cointault O, et al. Clinical Infectious Diseases 2014; 60(7): 997-1006
Various organs
Protocolized fluid therapy in brain-dead donors: the multicenter randomized MOnIToR trial
Al-Khafaji A, Elder M, et al Intensive Care Medicine 2015; 41(3): 418-26
Randomized, double-blind comparison of standard-dose vs. high-dose trivalent inactivated influenza vaccine in paediatric solid organ transplant patients
GiaQuinta S, Michaels MG, et al. Pediatric Transplantation 2015: 19: 219-228.