To keep the transplantation community informed about recently published level 1 evidence in organ transplantation ESOT and the Centre for Evidence in Transplantation have developed the Transplant Trial Watch.
The Transplant Trial Watch is a monthly overview of 10 new randomised controlled trials (RCTs) and systematic reviews. It includes a brief description of each study, an assessment of the reporting of some methodological quality features and the main conclusions of the report written by the Centre for Evidence in Transplantation (CET). RCTs and systematic reviews are selected by the Centre for Evidence in Transplantation on the basis of quality or interest. Electronic publications ahead of print are listed as [record in progress].
The first issue of the Transplant Trial Watch was published in September 2009. It is now made available to thousands of transplant professionals worldwide each month.
Click on each trial for more detail of findings and quality.
February 2017
Kidney transplantation
Safety and Efficacy Outcomes 3 Years After Switching to Belatacept From a Calcineurin Inhibitor in Kidney Transplant Recipients: Results From a Phase 2 Randomized Trial.
Grinyo JM, Del Carmen Rial M, et al. American Journal of Kidney Diseases 2016 [record in progress]
Diagnostic Performance of Fas Ligand mRNA Expression for Acute Rejection after Kidney Transplantation: A Systematic Review and Meta-Analysis.
Heng B, Ding H, et al. PLoS ONE 2016; 11(11): e0165628.
Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients.
Ishida JH, Patel A, et al. Antimicrobial Agents and Chemotherapy 2016 [record in progress]
Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study.
O'Connell PJ, Zhang W, et al. Lancet 2016; 388(10048): 983-993.
Automated Reminders and Physician Notification to Promote Immunosuppression Adherence Among Kidney Transplant Recipients: A Randomized Trial.
Reese PP, Bloom RD, et al. American Journal of Kidney Diseases 2016 [record in progress]
Telemedically-supported case management of living-donor renal transplant recipients to optimize routine evidence-based aftercare: A single-center randomized controlled trial.
Schmid A, Hils S, et al. American Journal of Transplantation 2016 [record in progress]
Liver transplantation
Efficacy and Safety of Simeprevir and Sofosbuvir With and Without Ribavirin in Subjects With Recurrent Genotype 1 Hepatitis C Post-Orthotopic Liver Transplant: The Randomized GALAXY Study.
O'Leary JG, Fontana RJ, et al. Transplant International 2016 [record in progress]
Temporary Intraoperative Porto-Caval Shunts in Piggy-Back Liver Transplantation Reduce Intraoperative Blood Loss and Improve Postoperative Transaminases and Renal Function: A Meta-Analysis.
Pratschke S, Rauch A, et al. World Journal of Surgery 2016; 40(12): 2988-2998.
Glycemic Control Reduces Infections in Post-Liver Transplant Patients: Results of a Prospective, Randomized Study.
Wallia A, Schmidt K, et al. The Journal of Clinical Endocrinology & Metabolism 2016 [record in progress]
Heart transplantation
Outcomes in adult congenital heart disease patients undergoing heart transplantation: A systematic review and meta-analysis.
Doumouras BS, Alba AC, et al. Journal of Heart & Lung Transplantation 2016; 35(11): 1337-1347.