The February 2012 Transplant Trial Watch is now online. Each month, the CET staff pick 10 recent randomised trials in transplantation and summarise them, assessing the methodological quality. This month, there are trials in renal, hepatic and cardiac transplantation, including a comparison of CsA/AZA and Tac/MMF in renal transplant recipients and the impact of MMF […]
This fascinating report appeared in the Lancet on line in the last couple of weeks (Jungebluth et al Nov 24, 2011). This is a single case report from a team led by Paolo Macchiarini who three years ago reported the first tissue engineered tracheal transplantation with a non immunogenic scaffold of allogeneic human donor trachea […]
In the December 1st issue of the New England Journal of Medicine are two very interesting reports. The first from Koreth et al (2011; 365:2055-66) has studied the use of low dose interleukin-2 (IL-2) in chronic graft versus host disease following allogeneic haematopoietic stem cell transplantation for haematologic cancer that was resistant to steroid therapy. […]
For some time now the CET has been producing a summary of ten of the months’ most important trials in transplantation for the European Society of Transplantation (ESOT). We are pleased to announce that this Trial Watch is now available on the CET website. Each month, ten important trials in transplantation are appraised for quality […]
The Transplant Trial Watch (TTW) provides a montly overview of 10 randomized controlled trials (RCTs) in organ transplantation that were added to the Transplant Library in the past month including RCTs that are published online only ahead of print. From this month we have added some more information about each selected RCT. The TTW now includes […]
At the Centre for Evidence in Transplantation (CET) we have been rating the methodological quality of randomised controlled trials (RCTs) published since 2004. The quality score is a composite score assessing allocation concealment, intention to treat (ITT) analysis and the Jadad scale which comprises items on the adequate description of randomisation, double blinding and withdrawals. […]
I read with some interest a case series in this month’s AJT from a group in India, reporting an initial experience of laparoscopic kidney transplantation (AJT 2011; 11: 1320). Modi and colleagues provide the rationale that transplant patients are at increased risk of wound related complications (due to renal failure and immunosuppression) and so a […]