Immortal time bias in survival analysis

By: Simon Knight | Posted on 17th December 2018

Whilst reviewing an article submitted to a transplant journal recently, my attention was brought to an issue that is often overlooked in survival analysis, called ‘immortal time bias’. The issue arises when the groups to be compared in the analysis are defined by a time-dependent event that can occur any time during follow-up. As standard […]

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Sirolimus use and cancer incidence in US kidney transplant recipients

By: Peter Morris | Posted on 10th February 2015

Recently we added to the Library as well as a blog  a very good individual patient meta-analysis of the use of sirolimus showing that it was associated with a reduction in cancer incidence but also with an increased rate of death after kidney transplantation.  Now we have a study of data from the US transplant registry […]

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Tacrolimus maintenance doses

By: Peter Morris | Posted on 27th March 2014

The Collaborative Transplant Study ( CTS ) first newsletter for 2014 (February 1 – available to CTS participants only) presents a particularly important analysis of outcomes of deceased donor kidneys between 2003 and 2012 based on the tacrolimus trough levels one year after transplantation. If the maintenance trough levels were less than 5ng/mL there was a significantly worse graft […]

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Liver transplantation from DCD donors in the UK

By: Peter Morris | Posted on 3rd October 2013

This interesting cohort study has just been published in BMJ Open and suggests that the recipients of DCD livers after risk adjustment have twice the risk of graft loss and death within 3 years of transplantation than recipients of livers from DBD donors. However there is a considerable difference in outcomes between the seven UK transplant […]

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HLA mismatch is associated with death with a functioning graft after kidney transplantation

By: Peter Morris | Posted on 2nd January 2013

In this interesting analysis from the Collaborative Transplant Study the authors have analysed some 180,000 deceased donor kidney transplants performed between 1990 and 2009 and have found that the incidence of death with a functioning graft was 4.8% during the first year after transplant and 7.7% during years 2-5. The most frequent causes of death […]

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Marked differences in kidney graft survival between Europe and the USA

By: Peter Morris | Posted on 15th November 2012

This very interesting study is in publication in Transplantation. It is an analysis of deceased donor kidney graft survival in Europe and the USA based on CTS data and UNOS data comparing overall and age specific 1, 5 and 10 year graft survival for Europeans and white, African and Hispanic Americans over a 3 year […]

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HLA matching and death with a functioning graft

By: Peter Morris | Posted on 17th September 2012

An analysis just produced by the Collaborative Transplant Study (CTS) (Newsletter 3; 2012) examined the most frequent cause of death in relation to HLA compatibility in the first 3 years after renal transplantation. The most frequent causes of death were infection (27%), cardiovascular disease (30%) and cancer (8%). It appeared that there were more deaths […]

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