I was very amused (and slightly horrified) by the Cochrane Hepato-Biliary group’s most recent offering regarding surgical resection versus liver transplantation for hepatocellular carcinoma. The 22-page review details elegantly the background to the review, gives an in depth search strategy and description of excluded studies and then concludes: “There are no randomised clinical trials comparing […]
At a meeting today I was introduced to a new website aimed at students interested in evidence-based medicine. Students 4 Best Evidence (S4BE for short) is written by an international panel of medical students, and includes articles and tutorials on EBM, resource reviews and articles on recent systematic review and trials. As would be expected […]
The August 2013 edition of the Transplant Trial Watch is now available online, and via our iPhone, iPad and Android app. This month, trials include Mizoribine in renal transplantation, retroperitoneoscopic donor nephrectomy and biopsy reporting following lung transplant.
A group from Sun Yat-sen University, Guangzhou, China has recently published a systematic review comparing the outcomes in patients receiving kidneys from donation after cardiac death (DCD). Deng et al conducted a meta-analysis using the results from four randomised controlled trials (351 kidneys). Machine perfusion reduced the rate of delayed graft function compared to static […]
The February 2013 edition of the Transplant Trial Watch is now available on the CET website, and via our app for Android and iPhone. Each month the CET staff identify 10 new trials in the field of transplantation to summarise and assess the quality. This month, the trial watch includes trials of early versus late […]
Happy New Year to all of our readers! The January 2013 edition of the Transplant Trial is now available, with 10 recently published trials in the field of solid organ transplantation selected and appraised for quality. This month, there are results of pre-transplant antiviral therapy in liver transplantation, intensive insulin therapy in diabetic renal transplant […]
The October edition of the Transplant Trial Watch is now available on the CET website. Each month, our team summarise and assess the quality of 10 important randomised controlled trials in the field of solid organ transplantation. This month, trials include sirolimus in the prevention of skin cancer in transplant recipients, machine perfusion in extended […]
This is quite a fascinating study and is a phase 2 randomised double blind study of cellular treatment of venous ulcers. Patients with non healing venous ulcers of the lower leg were treated with either the vehicle (fibrinogen and thrombin) – control group or with 4 different protocols of the vehicle with fibroblast and keratinocyte […]
Sylvie Euvrard and her colleagues (New England Journal of Medicine 2012; 367:329) have performed a multicentre randomised trial in patients on a calcineurin inhibitor who had developed at least 1 squamous cell cancer of the skin after renal transplantation. Patients were randomised to either continue on the calcineurin inhibitor or to be converted to sirolimus. […]