Help us to prioritise the most important questions in kidney transplantation

By: Simon Knight | Posted on 10th November 2015

The Centre for Evidence in Transplantation are currently leading a project to identify and prioritise unanswered research questions in kidney transplantation to help guide future research. The Kidney Transplant Priorities Setting Partnership has identified 45 unanswered questions, submitted by patients, clinicians, donors and carers. We are now trying to prioritise these questions to see which […]

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Deviation from intention-to-treat analysis alters treatment effect

By: John O'Callaghan | Posted on 12th June 2015

A recent article in the BMJ by Abraha et al, using large amounts of data from RCTs, has shown that deviation from intention-to-treat analysis (ITT) can lead to apparently larger treatment effects. When compared to standard intention-to-treat analysis there was a significant difference in the apparent treatment effect. When a deviation from ITT was compared […]

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Kidney Transplant PSP – report of progress

By: Simon Knight | Posted on 31st March 2015

As you may be aware, the Centre for Evidence in Transplantation is co-ordinating the James Lind Alliance Priorities Setting Partnership in Renal Transplantation.  The process aims to bring together pateints, carers and heathcare professionals to identify and prioritise areas for future research in kidney transplantation. The second steering group meeting was held at the Royal […]

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Meta-analysis in R: Part 2 – Binary data

By: Simon Knight | Posted on 5th August 2014

In part 1, I discussed how to get set up for meta-analysis in R, by installing the necessary software and libraries. In this post, I will take the reader through the steps for performing meta-analysis of binary data in R.

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Meta-analysis in R: Part 1 – Installing the software

By: Simon Knight | Posted on 18th July 2014

When I am teaching about meta-analysis on the EVIT course, I often moan about the inflexibility of Cochrane’s Revman software and am asked what I use to perform my meta-analyses. My pechant for open-source software led me to use the R statistical environment. In this series of blog posts, that I will update over the […]

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New feature: Expert commentaries in the Transplant Library

By: Liset Pengel | Posted on 26th June 2014

From this month the Transplant Library includes invited commentaries by transplantation experts. The commentary includes a clinical impact rating and also indicates whether the trial is considered practice changing. The randomised controlled trial “De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial” by Asrani and […]

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Origins of Evidence Based Medicine

By: Peter Morris | Posted on 21st February 2014

There was an interesting editorial by Richard Smith and Drummond Rennie in the BMJ recently. The editorial is based on two interviews of pioneers in this field by Richard Smith, the former editor of the BMJ. In the first oral history he interviews Iain Chalmers, Muir Gray and David Sackett. They said that authors from a […]

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Evidence in Transplantation (EVIT course): Last few places

By: Liset Pengel | Posted on 13th February 2014

The deadline to register for the Evidence in Transplantation (EVIT) course has been extended and you can now apply for one of the last few places of this highly rated course. EVIT last call The EVIT course is organised in collaboration with ESOT and will run on 21 and 22 March 2014 at the Royal College […]

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Apply now for the Evidence in Transplantation Course 2014!

By: Simon Knight | Posted on 12th December 2013

The deadline is approaching for the 2014 Evidence in Transplantation (EVIT) course, run by the CET and ESOT.  Applications must be in by the 30th January 2014. The course will run on the 21st and 22nd March 2014 at the Royal College of Surgeons, London, UK.   The two-day course  is aimed at professionals from […]

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Trial methodology – is it small-print?

By: Simon Knight | Posted on 23rd August 2013

As any regular reader of peer-reviewed journals will know, the most important section of any paper is the description of methods.  Without the information in the methods section it is almost impossible to interpret the results of a paper and determine whether the author’s conclusions are justified.  Indeed, it is often justifiable to bin a […]

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