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10th November 2015 / Last updated : 10th November 2015 Simon Knight PSP

Help us to prioritise the most important questions in kidney transplantation

The Centre for Evidence in Transplantation are currently leading a project to identify and prioritise unanswered research questions in kidney transplantation to help guide future research. The Kidney Transplant Priorities Setting Partnership has identified 45 unanswered questions, submitted by patients, clinicians, donors and carers. We are now trying to prioritise these questions to see which […]

12th June 2015 / Last updated : 12th June 2015 John O'Callaghan Journals

Deviation from intention-to-treat analysis alters treatment effect

A recent article in the BMJ by Abraha et al, using large amounts of data from RCTs, has shown that deviation from intention-to-treat analysis (ITT) can lead to apparently larger treatment effects. When compared to standard intention-to-treat analysis there was a significant difference in the apparent treatment effect. When a deviation from ITT was compared […]

31st March 2015 / Last updated : 31st March 2015 Simon Knight PSP

Kidney Transplant PSP – report of progress

As you may be aware, the Centre for Evidence in Transplantation is co-ordinating the James Lind Alliance Priorities Setting Partnership in Renal Transplantation.  The process aims to bring together pateints, carers and heathcare professionals to identify and prioritise areas for future research in kidney transplantation. The second steering group meeting was held at the Royal […]

5th August 2014 / Last updated : 5th August 2014 Simon Knight Meta-analysis in R

Meta-analysis in R: Part 2 – Binary data

In part 1, I discussed how to get set up for meta-analysis in R, by installing the necessary software and libraries. In this post, I will take the reader through the steps for performing meta-analysis of binary data in R.

18th July 2014 / Last updated : 18th July 2014 Simon Knight Meta-analysis in R

Meta-analysis in R: Part 1 – Installing the software

When I am teaching about meta-analysis on the EVIT course, I often moan about the inflexibility of Cochrane’s Revman software and am asked what I use to perform my meta-analyses. My pechant for open-source software led me to use the R statistical environment. In this series of blog posts, that I will update over the […]

26th June 2014 / Last updated : 26th June 2014 Liset Pengel Transplant library

New feature: Expert commentaries in the Transplant Library

From this month the Transplant Library includes invited commentaries by transplantation experts. The commentary includes a clinical impact rating and also indicates whether the trial is considered practice changing. The randomised controlled trial “De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial” by Asrani and […]

21st February 2014 / Last updated : 21st February 2014 Peter Morris Journals

Origins of Evidence Based Medicine

There was an interesting editorial by Richard Smith and Drummond Rennie in the BMJ recently. The editorial is based on two interviews of pioneers in this field by Richard Smith, the former editor of the BMJ. In the first oral history he interviews Iain Chalmers, Muir Gray and David Sackett. They said that authors from a […]

13th February 2014 / Last updated : 13th February 2014 Liset Pengel Courses

Evidence in Transplantation (EVIT course): Last few places

The deadline to register for the Evidence in Transplantation (EVIT) course has been extended and you can now apply for one of the last few places of this highly rated course. EVIT last call The EVIT course is organised in collaboration with ESOT and will run on 21 and 22 March 2014 at the Royal College […]

12th December 2013 / Last updated : 12th December 2013 Simon Knight Courses

Apply now for the Evidence in Transplantation Course 2014!

The deadline is approaching for the 2014 Evidence in Transplantation (EVIT) course, run by the CET and ESOT.  Applications must be in by the 30th January 2014. The course will run on the 21st and 22nd March 2014 at the Royal College of Surgeons, London, UK.   The two-day course  is aimed at professionals from […]

23rd August 2013 / Last updated : 23rd August 2013 Simon Knight Journals

Trial methodology – is it small-print?

As any regular reader of peer-reviewed journals will know, the most important section of any paper is the description of methods.  Without the information in the methods section it is almost impossible to interpret the results of a paper and determine whether the author’s conclusions are justified.  Indeed, it is often justifiable to bin a […]

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Recent posts

Sir Peter Morris 1934-2022

2nd November 2022

Successful 2022 ESOT ACADEMIA course in Rome

11th April 2022

Seeking motivated students or fellows to contribute to a qualitative evidence synthesis in organ donation.

16th November 2021

Value of Systematic Reviews and Meta-Analyses in Surgery

1st November 2021

CET wins government funding for a project exploring AI-driven decision support in organ offering

16th June 2021

New Transplant Evidence App released!

21st December 2020

COPE COMPARE study published in the Lancet

20th November 2020

COVID-19 resources in the Transplant Library

31st March 2020

January 2019 Transplant Trial Watch is now available

4th January 2019

Immortal time bias in survival analysis

17th December 2018

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