News

February 2018 Transplant Trial Watch Now available

By: Simon Knight | Posted on 5th February 2018

The February 2018 Transplant Trial Watch is now available. This month’s articles include the results of the Borteject trial, results of the UK 3C study and a review of guidelines for cancer evaluation in solid organ transplant recipients.

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May 2017 Transplant Trial Watch now online

By: Simon Knight | Posted on 2nd May 2017

The May 2017 edition of the Transplant Trial watch is now out. This month’s studies include low dose valganciclovir prophylaxis in renal transplantation, metal vs. plastic stents for anastomotic strictures in liver transplantation and ex-vivo perfusion in cardiac transplantation.

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Quality and consistency of outcome reporting in transplant clinical trials

By: Simon Knight | Posted on 3rd November 2016

Much focus is placed upon the methodological quality of clinical trials, and the impact that it has on the risk of bias at a study level.  An often neglected area is the reporting quality of the manuscripts from trials, which can also have a big impact on the interpretation of results. A recent paper in […]

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The explosion of systematic reviews – have we gone too far?

By: Simon Knight | Posted on 14th September 2016

A fascinating recent paper from Professor John Ioannidis from Stanford University, published in the Milbank Quarterly, has examined the explosion in the publication of systematic reviews and meta-analyses over recent years. Publications between 1991 and 2014 increased by 2,728% for systematic reviews, and 2,635% for meta-analyses – far in excess of the rate of publication […]

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September 2016 Transplant Trial Watch now available

By: Simon Knight | Posted on 5th September 2016

The September 2016 edition of the Transplant Trial Watch is now available. This month’s studies include include the perils of late CNI withdrawal, CNI to mTORi conversion in Liver Transplant recipients and computer-based home education.

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July 2016 Transplant Trial Watch now available

By: Simon Knight | Posted on 1st July 2016

The July 2016 edition of the Transplant Trial Watch is now available. This month, trials include long-term outcomes from BENEFIT-EXT, treatment of asymptomatic bacteriuria in renal transplant recipients and and in depth analysis of the VICTOR trial.

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May 2016 Transplant Trial Watch now available

By: Simon Knight | Posted on 29th April 2016

The May 2016 Transplant Trial Watch is now available online and via our app for iPhone, iPad and Android. This months new trials include long-term follow-up from the Spare the Nephron trial, methods for promoting organ donation and mobile medical apps for encouraging sun protection behaviour.

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March 2016 Transplant Trial Watch now available

By: Simon Knight | Posted on 1st March 2016

The March edition of the Transplant Trial Watch is now available via our website and the Trial Watch App. This month’s trials include the effect of Omega-3 on hepatic regeneration after live liver donation, prophylactic azithromycin after lung transplantation, and the consequences of complete tacrolimus withdrawal in renal transplant recipients.

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SONG-TX – developing a core outcome set for renal transplantation

By: Simon Knight | Posted on 17th February 2016

Many clinical trials have been conducted in kidney transplantation but a wide variety of different outcomes are reported and in different ways, and it is unclear whether they are important to people who have received a kidney transplant. There has been no agreement about what are the most important outcomes to measure and report in […]

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Placebo controls in surgical trials

By: Simon Knight | Posted on 2nd February 2016

There is an excellent article in this month’s Bulletin of the Royal College of Surgeons of England about the use of placebo surgery in clinical trials of surgical interventions. The article discusses many of the practical and ethical issues around the use of placebo procedures, including when they should and should not be considered. Interestingly, […]

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