The May 2018 edition of the Transplant Trial Watch is now available online. This month’s studies include the impact of allograft nephrectomy on subsequent transplants, the mid- and long-term risks of living kidney donation, and the use of transcatheter arterial embolisation in patients with APKD prior to transplant.
The first of the Consortium for Organ Preservation in Europe (COPE) organ preservation trials has now been published in Nature. The large, European, multicentre trial randomised livers to standard static cold storage, or to normothermic machine preservation using the OrganOx Metra device. The study demonstrated improved early biochemical function, with a reduction in peak ALT […]
The March 2018 Transplant Trial watch is now available online and via the CET app. This month’s papers include an evaluation of inclusion/exclusion criteria in transplant clinical trials, self-monitoring of kidney function after transplantation and extended versus modified right lobe grafts for live donor liver transplantation.
The European Society in Organ Transplantation and the Centre for Evidence in Transplantation have teamed up to create a new course for future leaders in transplantation. Replacing the Evidence in Transplantation (EVIT) course and European Transplant Fellows Workshop (ETFW), this new course aims to teach: Academic skills – research, critical appraisal, evidence based medicine, systematic […]
Renal transplant recipients and donors are becoming increasingly more marginal, with more expanded criteria (ECD) and donation after circulatory death (DCD) donors and increasingly older recipients with multiple comorbidities. Despite this, high-risk donors and recipients are often excluded from clinical trials, leading to uncertainty about the generalizability of findings. In order to highlight the extent of this […]
The July 2017 edition of the Transplant Trial Watch is now available. This month’s papers include a systematic review of factors affecting medication adherence following renal transplant, a trial of Belatacept versus tacrolimus in renal transplant recipients and a systematic review of transplant tourism.
Much focus is placed upon the methodological quality of clinical trials, and the impact that it has on the risk of bias at a study level. An often neglected area is the reporting quality of the manuscripts from trials, which can also have a big impact on the interpretation of results. A recent paper in […]
As many of you are now aware, Peter Morris has formally announced that he is retiring from his role as director of the Centre for Evidence in Transplantation. Peter established the CET in 2005 with the aim of improving the quality of evidence in solid organ transplantation and increasing awareness of evidence-based medicine amongst transplant […]